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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2008-5-2
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pubmed:abstractText |
Survivin (BIRC5) is a promising tumor biomarker. Conflicting data exist on its prognostic effect in breast cancer. These data may at least be partly due to the manual interpretation of immunohistochemical staining, especially as survivin can be located in both the nucleus and cytoplasm. Quantitative determination of survivin expression using image analysis offers the opportunity to develop alternative scoring models for survivin immunohistochemistry. Here, we present such a model.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1078-0432
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pubmed:author |
pubmed-author:BrennanDonal JDJ,
pubmed-author:CulhaneAedín CAC,
pubmed-author:DuffyMichael JMJ,
pubmed-author:FaganAilísA,
pubmed-author:GallagherWilliam MWM,
pubmed-author:HewittStephen MSM,
pubmed-author:HigginsDesmond GDG,
pubmed-author:JirstromKarinK,
pubmed-author:LandbergGoranG,
pubmed-author:McSherryElaineE,
pubmed-author:MillikanRobert CRC,
pubmed-author:O'BrienSallyann LSL,
pubmed-author:O'ConnorDarran PDP,
pubmed-author:RexhepajEltonE
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2681-9
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:18451232-Adult,
pubmed-meshheading:18451232-Aged,
pubmed-meshheading:18451232-Aged, 80 and over,
pubmed-meshheading:18451232-Breast Neoplasms,
pubmed-meshheading:18451232-Cell Line, Tumor,
pubmed-meshheading:18451232-Cell Nucleus,
pubmed-meshheading:18451232-Cytoplasm,
pubmed-meshheading:18451232-Female,
pubmed-meshheading:18451232-Humans,
pubmed-meshheading:18451232-Inhibitor of Apoptosis Proteins,
pubmed-meshheading:18451232-Microtubule-Associated Proteins,
pubmed-meshheading:18451232-Middle Aged,
pubmed-meshheading:18451232-Neoplasm Proteins,
pubmed-meshheading:18451232-Prognosis,
pubmed-meshheading:18451232-Regression Analysis,
pubmed-meshheading:18451232-Tissue Array Analysis,
pubmed-meshheading:18451232-Tumor Markers, Biological
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pubmed:year |
2008
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pubmed:articleTitle |
Altered cytoplasmic-to-nuclear ratio of survivin is a prognostic indicator in breast cancer.
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pubmed:affiliation |
UCD School of Biomolecular and Biomedical Science and UCD School of Medicine and Medical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin, Ireland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Intramural
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