Source:http://linkedlifedata.com/resource/pubmed/id/18423577
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
2008-5-12
|
| pubmed:abstractText |
Increasing evidence indicates that the beta2-adrenergic receptor (beta2-AR) may play an important role in Alzheimer's disease (AD). We investigated the effect of two polymorphisms in the beta2-AR gene: Gly16Arg and Gln27Glu for the risk of sporadic Late Onset Alzheimer's Disease (LOAD) in 109 patients and 109 healthy controls matched for sex and age in a Han Chinese population. Results revealed that both the 16Gly allele and the 27Glu allele of the beta2-AR gene were associated with an increased risk of LOAD (P=0.009, OR=1.652 and P=0.002, OR=2.846, respectively), and they also showed a highly significant interaction with the Apolipoprotein E gene (APOE) epsilon4 allele (OR=4.200 and 9.441, respectively). Examination of the haplotypes identified the Gly16Glu27 haplotype to increase the risk of LOAD (P=0.004). Our results suggest that variations in the beta2-AR gene play an important role in the pathogenesis of sporadic LOAD, and interact with the epsilon4 allele to markedly increase the LOAD risk.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
May
|
| pubmed:issn |
0006-8993
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
19
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| pubmed:volume |
1210
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
216-22
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| pubmed:dateRevised |
2009-11-19
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| pubmed:meshHeading |
pubmed-meshheading:18423577-Aged,
pubmed-meshheading:18423577-Alzheimer Disease,
pubmed-meshheading:18423577-Apolipoprotein E4,
pubmed-meshheading:18423577-Brain,
pubmed-meshheading:18423577-Brain Chemistry,
pubmed-meshheading:18423577-Catecholamines,
pubmed-meshheading:18423577-China,
pubmed-meshheading:18423577-DNA Mutational Analysis,
pubmed-meshheading:18423577-Female,
pubmed-meshheading:18423577-Gene Frequency,
pubmed-meshheading:18423577-Genetic Markers,
pubmed-meshheading:18423577-Genetic Predisposition to Disease,
pubmed-meshheading:18423577-Genetic Testing,
pubmed-meshheading:18423577-Genotype,
pubmed-meshheading:18423577-Haplotypes,
pubmed-meshheading:18423577-Humans,
pubmed-meshheading:18423577-Male,
pubmed-meshheading:18423577-Mutation,
pubmed-meshheading:18423577-Polymorphism, Genetic,
pubmed-meshheading:18423577-Receptors, Adrenergic, beta-2
|
| pubmed:year |
2008
|
| pubmed:articleTitle |
Polymorphisms at the beta2-adrenergic receptor gene influence Alzheimer's disease susceptibility.
|
| pubmed:affiliation |
Department of Neurology, Qingdao Municipal Hospital, Affiliated Hospital of Qingdao University Medical College, Shandong Province, PR China.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|