Source:http://linkedlifedata.com/resource/pubmed/id/18394461
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
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| pubmed:dateCreated |
2008-4-8
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| pubmed:abstractText |
Although cardiotoxic effects of highly active antiretroviral therapy (HAART) are a growing concern, there is a lack of prospective studies of subclinical involvement of the heart in human immunodeficiency virus (HIV)-infected patients. This study evaluated noninvasively cardiac morphologic characteristics and function in HIV-positive (HIV(+)) men receiving HAART for > or =2 years with no clinical evidence of cardiovascular disease. Echocardiography at rest, including tissue Doppler imaging and exercise testing, were performed in 30 HIV(+) men (age 42.1 +/- 4.7 years, duration of HIV infection 10.4 +/- 4.7 years, duration of HAART 5.3 +/- 2.1 years) and 26 age-matched healthy controls. At rest, HIV(+) patients had similar left ventricular (LV) mass indexed to height(2.7) (40.6 +/- 9.5 vs 37.5 +/- 9.3 g/m; p >0.05), but a higher prevalence of LV diastolic dysfunction (abnormal relaxation or pseudonormal filling pattern in 64% of patients vs 12% of controls; p <0.001). LV systolic function indexes were significantly lower (ejection fraction 60.4 +/- 8.7% vs 66.9 +/- 6.9%; p <0.01, and tissue Doppler imaging peak systolic velocity 11.4 +/- 1.6 vs 13.5 +/- 2.2 cm/s; p <0.001). Pulmonary artery pressure was higher in patients compared with controls (32.1 +/- 5.4 vs 26.1 +/- 6.5 mm Hg; p <0.001). Exercise testing showed decreased exercise tolerance in HIV(+) patients, with no case of myocardial ischemia. In conclusion, subclinical cardiac abnormalities are frequently observed in HIV(+) patients on HAART. The usefulness of systematic noninvasive screening in this population should be considered. GECEM study no. 30: National Agency for AIDS Research (ANRS).
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| pubmed:commentsCorrections | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:status |
MEDLINE
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| pubmed:month |
Apr
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| pubmed:issn |
0002-9149
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| pubmed:author |
pubmed-author:BoccaraFranckF,
pubmed-author:CohenArielA,
pubmed-author:DauzatMichelM,
pubmed-author:EdérhyStéphaneS,
pubmed-author:GirardPierre-MariePM,
pubmed-author:KhireddineMohamedM,
pubmed-author:MauboussinJean-MarcJM,
pubmed-author:Messner-PellencPatrickP,
pubmed-author:NottinStéphaneS,
pubmed-author:ObertPhilippeP,
pubmed-author:RouanetIsabelleI,
pubmed-author:SchusterIrisI,
pubmed-author:ThöniGilles JacquesGJ,
pubmed-author:VinetAgnèsA,
pubmed-author:WaltherGuillaumeG
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| pubmed:issnType |
Print
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| pubmed:day |
15
|
| pubmed:volume |
101
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1213-7
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| pubmed:dateRevised |
2008-9-11
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| pubmed:meshHeading |
pubmed-meshheading:18394461-Adult,
pubmed-meshheading:18394461-Antiretroviral Therapy, Highly Active,
pubmed-meshheading:18394461-Blood Flow Velocity,
pubmed-meshheading:18394461-Blood Pressure,
pubmed-meshheading:18394461-Case-Control Studies,
pubmed-meshheading:18394461-Diastole,
pubmed-meshheading:18394461-Echocardiography,
pubmed-meshheading:18394461-Exercise Test,
pubmed-meshheading:18394461-Exercise Tolerance,
pubmed-meshheading:18394461-HIV Infections,
pubmed-meshheading:18394461-Heart Rate,
pubmed-meshheading:18394461-Heart Ventricles,
pubmed-meshheading:18394461-Humans,
pubmed-meshheading:18394461-Male,
pubmed-meshheading:18394461-Prospective Studies,
pubmed-meshheading:18394461-Rest,
pubmed-meshheading:18394461-Stroke Volume,
pubmed-meshheading:18394461-Systole,
pubmed-meshheading:18394461-Ventricular Dysfunction, Left
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| pubmed:year |
2008
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| pubmed:articleTitle |
Subclinical cardiac abnormalities in human immunodeficiency virus-infected men receiving antiretroviral therapy.
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| pubmed:affiliation |
Cardiology Department, University Hospital Carémeau, Nîmes, France.
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| pubmed:publicationType |
Journal Article
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