rdf:type |
|
lifeskim:mentions |
umls-concept:C0007600,
umls-concept:C0015683,
umls-concept:C0017262,
umls-concept:C0086418,
umls-concept:C0185117,
umls-concept:C0242184,
umls-concept:C0259565,
umls-concept:C0334227,
umls-concept:C0376358,
umls-concept:C0439849,
umls-concept:C2911684
|
pubmed:issue |
3
|
pubmed:dateCreated |
2008-3-21
|
pubmed:abstractText |
Positron emission tomography (PET) imaging with copper (II)-diacetyl-bis(N4-Methylthiosemicarbazone)(Cu-ATSM) for delineating hypoxia has provided valuable clinical information, but investigations in animal models of prostate cancer have shown some inconsistencies. As a defense mechanism in prostate cancer cells, the fatty acid synthesis pathway harnesses its oxidizing power for improving the redox balance despite conditions of extreme hypoxia, potentially altering Cu-ATSM hypoxia selectivity.
|
pubmed:grant |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Apr
|
pubmed:issn |
0969-8051
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
35
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
273-9
|
pubmed:meshHeading |
pubmed-meshheading:18355682-4-Butyrolactone,
pubmed-meshheading:18355682-Cell Hypoxia,
pubmed-meshheading:18355682-Cell Line, Tumor,
pubmed-meshheading:18355682-Copper Radioisotopes,
pubmed-meshheading:18355682-Dose-Response Relationship, Drug,
pubmed-meshheading:18355682-Drug Synergism,
pubmed-meshheading:18355682-Fatty Acid Synthetase Complex,
pubmed-meshheading:18355682-Gene Expression,
pubmed-meshheading:18355682-Humans,
pubmed-meshheading:18355682-Male,
pubmed-meshheading:18355682-Organometallic Compounds,
pubmed-meshheading:18355682-Positron-Emission Tomography,
pubmed-meshheading:18355682-Prostatic Neoplasms,
pubmed-meshheading:18355682-Radiopharmaceuticals,
pubmed-meshheading:18355682-Thiosemicarbazones
|
pubmed:year |
2008
|
pubmed:articleTitle |
Examining the relationship between Cu-ATSM hypoxia selectivity and fatty acid synthase expression in human prostate cancer cell lines.
|
pubmed:affiliation |
Division of Radiological Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
|