{
  "http://linkedlifedata.com/resource/pubmed/id/18204779" : {
    "http://linkedlifedata.com/resource/pubmed/authorsComplete" : [ {
      "value" : "Y",
      "type" : "literal"
    } ],
    "http://linkedlifedata.com/resource/pubmed/abstractText" : [ {
      "value" : "Cysteinyl-leukotrienes are important pro-inflammatory mediators in bronchial asthma (BA) and are derived from arachidonic acid by the action of 5-lipoxygenase. We identified a novel polymorphism, c.760 G>A (E254K), in exon 6 of the 5-lipoxygenase gene (5-LO). This substitution was detected in 11 out of 180 patients with BA, but not in any of the 150 non-allergic subjects. The frequency of c.760 G>A showed a significant difference between BA and non-allergic subjects (P=0.0007). The c.760 G>A polymorphism existed at the surface edge of the C-terminal catalytic domain, and the E-to-K substitution changed the charge of the side chain from negative to positive. Thus, our results suggest that E254K in the 5-LO might be associated with BA.",
      "type" : "literal"
    } ],
    "http://linkedlifedata.com/resource/pubmed/author" : [ {
      "value" : "http://linkedlifedata.com/resource/pubmed/author/KondoNaomiN",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/author/FukaoToshiyukiT",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/author/KanekoHideoH",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/author/MatsuiEikoE",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/author/KatoZenichiroZ",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/author/KasaharaKimikoK",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/author/OhnishiHidenoriH",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/author/BaiChunyingC",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/author/KimataKaoriK",
      "type" : "uri"
    } ],
    "http://linkedlifedata.com/resource/pubmed/status" : [ {
      "value" : "MEDLINE",
      "type" : "literal"
    } ],
    "http://linkedlifedata.com/resource/pubmed/year" : [ {
      "value" : "2008",
      "type" : "literal"
    } ],
    "http://linkedlifedata.com/resource/pubmed/owner" : [ {
      "value" : "NLM",
      "type" : "literal"
    } ],
    "http://linkedlifedata.com/resource/lifeskim/mentions" : [ {
      "value" : "http://linkedlifedata.com/resource/umls/id/C0004096",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/umls/id/C0017337",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/umls/id/C0003693",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/umls/id/C0332281",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/umls/id/C1882417",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/umls/id/C0679622",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/umls/id/C0205314",
      "type" : "uri"
    } ],
    "http://linkedlifedata.com/resource/pubmed/volume" : [ {
      "value" : "21",
      "type" : "literal"
    } ],
    "http://linkedlifedata.com/resource/pubmed/citationSubset" : [ {
      "value" : "IM",
      "type" : "literal"
    } ],
    "http://linkedlifedata.com/resource/pubmed/articleTitle" : [ {
      "value" : "A novel polymorphism, E254K, in the 5-lipoxygenase gene associated with bronchial asthma.",
      "type" : "literal"
    } ],
    "http://linkedlifedata.com/resource/pubmed/chemical" : [ {
      "value" : "http://linkedlifedata.com/resource/pubmed/chemical/Lysine",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/chemical/RNA%2C+Messenger",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/chemical/Glutamic+Acid",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/chemical/Arachidonate+5-Lipoxygenase",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/chemical/Leukotriene+B4",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/chemical/Ionomycin",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/chemical/Leukotriene+E4",
      "type" : "uri"
    } ],
    "http://linkedlifedata.com/resource/pubmed/meshHeading" : [ {
      "value" : "http://linkedlifedata.com/resource/pubmed/meshheading/18204779-Humans",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/meshheading/18204779-Asthma",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/meshheading/18204779-Child",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/meshheading/18204779-Glutamic+Acid",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/meshheading/18204779-Lysine",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/meshheading/18204779-Female",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/meshheading/18204779-Male",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/meshheading/18204779-Models%2C+Molecular",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/meshheading/18204779-Base+Sequence",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/meshheading/18204779-RNA%2C+Messenger",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/meshheading/18204779-Gene+Frequency",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/meshheading/18204779-Neutrophils",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/meshheading/18204779-Polymorphism%2C+Genetic",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/meshheading/18204779-Molecular+Sequence+Data",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/meshheading/18204779-Genetic+Predisposition+to+Disease",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/meshheading/18204779-Gene+Expression+Regulation%2C+Enzymologic",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/meshheading/18204779-Ionomycin",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/meshheading/18204779-Leukotriene+B4",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/meshheading/18204779-Leukotriene+E4",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/meshheading/18204779-Arachidonate+5-Lipoxygenase",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/meshheading/18204779-DNA+Mutational+Analysis",
      "type" : "uri"
    }, {
      "value" : "http://linkedlifedata.com/resource/pubmed/meshheading/18204779-Structural+Homology%2C+Protein",
      "type" : "uri"
    } ],
    "http://linkedlifedata.com/resource/pubmed/pagination" : [ {
      "value" : "139-44",
      "type" : "literal"
    } ],
    "http://linkedlifedata.com/resource/pubmed/month" : [ {
      "value" : "Feb",
      "type" : "literal"
    } ],
    "http://www.w3.org/1999/02/22-rdf-syntax-ns#type" : [ {
      "value" : "http://linkedlifedata.com/resource/pubmed/Citation",
      "type" : "uri"
    } ],
    "http://linkedlifedata.com/resource/pubmed/journal" : [ {
      "value" : "http://linkedlifedata.com/resource/pubmed/journal/9810955",
      "type" : "uri"
    } ],
    "http://linkedlifedata.com/resource/pubmed/issn" : [ {
      "value" : "1107-3756",
      "type" : "literal"
    } ],
    "http://linkedlifedata.com/resource/pubmed/issue" : [ {
      "value" : "2",
      "type" : "literal"
    } ],
    "http://linkedlifedata.com/resource/pubmed/dateCreated" : [ {
      "value" : "2008-1-21",
      "type" : "literal"
    } ],
    "http://linkedlifedata.com/resource/pubmed/affiliation" : [ {
      "value" : "Department of Pediatrics, Graduate School of Medicine, Gifu University, Gifu 501-1193, Japan.",
      "type" : "literal"
    } ],
    "http://linkedlifedata.com/resource/pubmed/publicationType" : [ {
      "value" : "Journal Article",
      "type" : "literal"
    }, {
      "value" : "Research Support, Non-U.S. Gov't",
      "type" : "literal"
    } ],
    "http://linkedlifedata.com/resource/pubmed/issnType" : [ {
      "value" : "Print",
      "type" : "literal"
    } ],
    "http://linkedlifedata.com/resource/pubmed/language" : [ {
      "value" : "eng",
      "type" : "literal"
    } ]
  }
}