Source:http://linkedlifedata.com/resource/pubmed/id/18035849
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2008-6-25
|
| pubmed:abstractText |
We assessed (1)H-MRS as a screening tool for detection of hippocampal sclerosis in patients with temporal lobe epilepsy (TLE). (1)H-MRS was carried out in the hippocampus of 23 patients with unilateral TLE. Metabolite alterations detected by (1)H-MRS correlated with degree of segmental neuronal cell loss and amount of astrogliosis. Positive correlation was found between total N-Acetylaspartate (tNAA) reduction and neuronal density in hippocampal CA1 (P < 0.001), CA3 (P = 0.015), and CA4 subfields (P = 0.031) and the dentate gyrus (P = 0.006). Neuronal cell loss in CA1 turned out to be the most predictive and only significant variable for tNAA reduction (P = 0.027). The association between myo-inositol (m-Ins) and astroglial glial fibrillary acidic protein (GFAP) expression revealed significantly increased m-Ins concentrations associated with diffuse astrogliosis (m-Ins = 6.4 +/- 1.1 institutional units) compared with gliosis restricted to isolated sectors of the hippocampus (i.e. hilus) (m-Ins = 5.2 +/- 1.2 institutional units) (P = 0.039). A negative correlation was found between m-Ins and neuronal loss in the CA4 subfield of the hippocampus (P = 0.028). Our results support (1)H-MRS as a suitable non-invasive method for preoperative identification of hippocampal sclerosis in patients with TLE. The extent of tNAA reduction correlates with hippocampal neuronal cell density. Furthermore, m-Ins is associated with the extent of hippocampal astrogliosis.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jul
|
| pubmed:issn |
0952-3480
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| pubmed:author |
pubmed-author:BlumckeIngmarI,
pubmed-author:DoelkenMarcM,
pubmed-author:DoerflerArndtA,
pubmed-author:EngelhornTobiasT,
pubmed-author:GanslandtOliverO,
pubmed-author:HammenThiloT,
pubmed-author:HildebrandtMichelleM,
pubmed-author:KasperBurkhardB,
pubmed-author:KerlingFrankF,
pubmed-author:NimskyChristopherC,
pubmed-author:RomstoeckJohannJ,
pubmed-author:StadlbauerAndreasA,
pubmed-author:StefanHermannH
|
| pubmed:issnType |
Print
|
| pubmed:volume |
21
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
545-52
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| pubmed:meshHeading |
pubmed-meshheading:18035849-Adolescent,
pubmed-meshheading:18035849-Adult,
pubmed-meshheading:18035849-Aspartic Acid,
pubmed-meshheading:18035849-Biological Markers,
pubmed-meshheading:18035849-Child,
pubmed-meshheading:18035849-Child, Preschool,
pubmed-meshheading:18035849-Epilepsy, Temporal Lobe,
pubmed-meshheading:18035849-Female,
pubmed-meshheading:18035849-Hippocampus,
pubmed-meshheading:18035849-Humans,
pubmed-meshheading:18035849-Infant,
pubmed-meshheading:18035849-Magnetic Resonance Spectroscopy,
pubmed-meshheading:18035849-Male,
pubmed-meshheading:18035849-Middle Aged,
pubmed-meshheading:18035849-Protons,
pubmed-meshheading:18035849-Reproducibility of Results,
pubmed-meshheading:18035849-Sclerosis,
pubmed-meshheading:18035849-Sensitivity and Specificity,
pubmed-meshheading:18035849-Statistics as Topic,
pubmed-meshheading:18035849-Tissue Distribution
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| pubmed:year |
2008
|
| pubmed:articleTitle |
Non-invasive detection of hippocampal sclerosis: correlation between metabolite alterations detected by (1)H-MRS and neuropathology.
|
| pubmed:affiliation |
Center Epilepsy Erlangen (ZEE), Department of Neurology, University of Erlangen-Nuremberg, Erlangen, Germany. thilo.hammen@uk-erlangen.de
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|