Linked Life Data

18022324

Source:http://linkedlifedata.com/resource/pubmed/id/18022324

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2007-12-17
pubmed:abstractText
mKirre is a novel member of the immunoglobulin superfamily, which is abundant in the developing and adult brain. In the present study, we showed mKirre gene expression in mouse sensory organs during development using in situ hybridization and immunohistochemistry. At embryonic day (E) 11.5, E15.5, and E17.5, we first detected signals for mKirre mRNA in the developing cochleae, retinae, and olfactory neuroepithelia, respectively. After birth, strong signals were observed in these sensory organs. In addition, at this stage, we found its expression in trigeminal ganglion neurons and neuronal populations forming sensory pathways in the olfactory bulb, midbrain, and pons. Furthermore, double-immunofluorescence staining revealed that nephrin-immunoreactivity was overlapping to mKirre-expressing cells in the developing sensory organs. These results suggest that mKirre may be involved in the establishment of the pathway from sensory organs to the brain not only in a homophilic manner but also with its heterophilic interaction to nephrin.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0306-4522
pubmed:author
pubmed:issnType
Print
pubmed:day
19
pubmed:volume
150
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
880-6
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Expression of mKirre in the developing sensory pathways: its close apposition to nephrin-expressing cells.
pubmed:affiliation
Department of Anatomy and Neurobiology, Wakayama Medical University, 811-1, Kimiidera, Wakayama 641-8509, Japan. yoshim@wakayama-med.ac.jp
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't