| pubmed-article:17950805 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17950805 | lifeskim:mentions | umls-concept:C0018824 | lld:lifeskim |
| pubmed-article:17950805 | lifeskim:mentions | umls-concept:C0115471 | lld:lifeskim |
| pubmed-article:17950805 | lifeskim:mentions | umls-concept:C1328247 | lld:lifeskim |
| pubmed-article:17950805 | lifeskim:mentions | umls-concept:C0004083 | lld:lifeskim |
| pubmed-article:17950805 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:17950805 | pubmed:dateCreated | 2007-10-22 | lld:pubmed |
| pubmed-article:17950805 | pubmed:abstractText | Valvular heart disease, inducing valvular regurgitation, has been described in users of drugs such as anorectic agents and ergot derivates. 3,4-Methylenedioxymethamphetamine (MDMA; "ecstasy") also leads in vitro to the proliferation of cardiac valvular interstitial cells by activation of the 5-hydroxytryptamine 2B receptor. The aim of this study was to determine the occurrence of valvulopathy in young adults taking MDMA. Twenty-nine subjects using or having used MDMA and 29 gender- and age-matched controls were blindly evaluated with echocardiography. Eight subjects (28%) who took MDMA had abnormal echocardiographic results using the United States Food and Drug Administration's criteria for appetite suppressant-induced valvular heart disease, compared with none in the control group (p = 0.0045). Six (21%) subjects had mitral regurgitation of 1/4 and 4 (14%) of > or =2/4, compared with none in the control group (p = 0.002). The mean mitral regurgitant area ratios (jet/atrium) were 12 +/- 9.8% and 5 +/- 1.3%, respectively (p = 0.007). Tricuspid regurgitation > or =2/4 was present in 13 MDMA users (45%) and absent in controls (p <0.001). The mean tricuspid regurgitant area ratios were 19 +/- 9.5% and 9 +/- 4.5%, respectively (p <0.001). Four MDMA users (14%) had mild aortic regurgitation (p = 0.11). Valvular "strands" were present in 6 MDMA users (21%) and in none of the controls (p = 0.02). In conclusion, MDMA may lead to mild to moderate valvular heart disease and valvular strands. | lld:pubmed |
| pubmed-article:17950805 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17950805 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17950805 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:17950805 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17950805 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17950805 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17950805 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:17950805 | pubmed:issn | 0002-9149 | lld:pubmed |
| pubmed-article:17950805 | pubmed:author | pubmed-author:FrankenPhilip... | lld:pubmed |
| pubmed-article:17950805 | pubmed:author | pubmed-author:Van CampGuyG | lld:pubmed |
| pubmed-article:17950805 | pubmed:author | pubmed-author:SchoorsDannyD | lld:pubmed |
| pubmed-article:17950805 | pubmed:author | pubmed-author:CosynsBernard... | lld:pubmed |
| pubmed-article:17950805 | pubmed:author | pubmed-author:Vandenbossche... | lld:pubmed |
| pubmed-article:17950805 | pubmed:author | pubmed-author:BenjaminScott... | lld:pubmed |
| pubmed-article:17950805 | pubmed:author | pubmed-author:WeytjensCarol... | lld:pubmed |
| pubmed-article:17950805 | pubmed:author | pubmed-author:D'haenenHugoH | lld:pubmed |
| pubmed-article:17950805 | pubmed:author | pubmed-author:DroogmansStev... | lld:pubmed |
| pubmed-article:17950805 | pubmed:author | pubmed-author:CloseLaurentL | lld:pubmed |
| pubmed-article:17950805 | pubmed:author | pubmed-author:KemdemArsèneA | lld:pubmed |
| pubmed-article:17950805 | pubmed:author | pubmed-author:CreetenEdwinE | lld:pubmed |
| pubmed-article:17950805 | pubmed:author | pubmed-author:BechetSergeS | lld:pubmed |
| pubmed-article:17950805 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17950805 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:17950805 | pubmed:volume | 100 | lld:pubmed |
| pubmed-article:17950805 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17950805 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17950805 | pubmed:pagination | 1442-5 | lld:pubmed |
| pubmed-article:17950805 | pubmed:meshHeading | pubmed-meshheading:17950805... | lld:pubmed |
| pubmed-article:17950805 | pubmed:meshHeading | pubmed-meshheading:17950805... | lld:pubmed |
| pubmed-article:17950805 | pubmed:meshHeading | pubmed-meshheading:17950805... | lld:pubmed |
| pubmed-article:17950805 | pubmed:meshHeading | pubmed-meshheading:17950805... | lld:pubmed |
| pubmed-article:17950805 | pubmed:meshHeading | pubmed-meshheading:17950805... | lld:pubmed |
| pubmed-article:17950805 | pubmed:meshHeading | pubmed-meshheading:17950805... | lld:pubmed |
| pubmed-article:17950805 | pubmed:meshHeading | pubmed-meshheading:17950805... | lld:pubmed |
| pubmed-article:17950805 | pubmed:meshHeading | pubmed-meshheading:17950805... | lld:pubmed |
| pubmed-article:17950805 | pubmed:meshHeading | pubmed-meshheading:17950805... | lld:pubmed |
| pubmed-article:17950805 | pubmed:meshHeading | pubmed-meshheading:17950805... | lld:pubmed |
| pubmed-article:17950805 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17950805 | pubmed:articleTitle | Possible association between 3,4-methylenedioxymethamphetamine abuse and valvular heart disease. | lld:pubmed |
| pubmed-article:17950805 | pubmed:affiliation | Department of Cardiology, Universitair Ziekenhuis Brussel, Brussels, Belgium. steven_droogmans@yahoo.com | lld:pubmed |
| pubmed-article:17950805 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17950805 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
