Linked Life Data

17931196

Source:http://linkedlifedata.com/resource/pubmed/id/17931196

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2007-10-12
pubmed:abstractText
Because some of the autoreactive T-cell clones specific for human PDC-E2 cross-react to mimicry peptides having an EIExDK motif derived from nuclear antigens such as human gp210 and sp100, we studied the clinical significance of antinuclear antibodies (ANA) in primary biliary cirrhosis (PBC) patients registered to the National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ). We found that there are two different types of progression in PBC; one is a hepatic failure-type progression which is represented by positive anti-gp210 antibodies and the other is a portalhypertension-type progression which is represented by positive anticentromere antibodies. We discuss the predictive role of these ANA in the long-term outcome of PBC and the mechanisms by which two different PBC progression types occur based on molecular mimicry and aberrant expression of nuclear antigens.
pubmed:language
eng
pubmed:journal
pubmed:status
PubMed-not-MEDLINE
pubmed:month
Oct
pubmed:issn
1386-6346
pubmed:author
pubmed:issnType
Print
pubmed:volume
37 Suppl 3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S412-9
pubmed:year
2007
pubmed:articleTitle
Predictive role of anti-gp210 and anticentromere antibodies in long-term outcome of primary biliary cirrhosis.
pubmed:affiliation
National Hospital Organization (NHO) Nagasaki Medical Center, Omura; Nagasaki University Graduate School of Biomedical Sciences, Nagasaki; and National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ), Fukuoka, Japan.
pubmed:publicationType
Journal Article