Linked Life Data

17912466

Source:http://linkedlifedata.com/resource/pubmed/id/17912466

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2007-10-3
pubmed:abstractText
Inflammatory changes in the gastric mucosa are commonly observed in Japanese patients with functional dyspepsia (FD). However, detailed data regarding the relationship between the genetic regulatory factors of inflammation and FD are not available. We investigated the associations between FD and genetic polymorphisms of molecules associated with inflammation or immune response (IL-17A, -17F and MIF). The study was performed with 278 subjects (188 with no upper abdominal symptoms and 90 with FD according to the Roma III criteria). We employed the PCR-SSCP (multiplex PCR for IL-17A and -17F) method to detect the gene polymorphisms. Overall, the polymorphisms of the IL-17A, -17F and MIF genes were not correlated with the susceptibility to FD. However, the MIF -173C allele carrier had a significantly increased risk for the development of epigastric pain syndrome (EPS) of FD (OR, 2.12; 95% CI, 1.00-4.49; p=0.0497). In Helicobacter pylori (H. pylori)-infected cases, the number of IL-17F 7488T alleles was positively correlated with the development of EPS (OR, 11.3; 95% CI, 1.23-103.2; p=0.032), while the IL-17F T/T homozygote and the MIF -173C carrier had an increased risk for EPS (OR, 10.4; 95% CI, 1.17-92.3; p=0.036 and OR, 3.66; 95% CI, 1.19-11.3; p=0.024, respectively). In addition, a significant interaction between the IL-17F 7488 polymorphism and H. pylori infection was shown to increase the activity and inflammation scores (p=0.043 and 0.042, respectively). There were no significant associations between the IL-17A polymorphism and FD. Our results provide the first evidence that the IL-17F and MIF gene polymorphisms are significantly associated with the development of FD, particularly EPS, a subgroup of FD, in H. pylori-infected subjects. The genetic polymorphisms of inflammation or immune response-related molecules are involved in the development of one of the FD subgroups via H. pylori-induced gastric inflammation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1107-3756
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
717-23
pubmed:meshHeading
pubmed-meshheading:17912466-Adult, pubmed-meshheading:17912466-Analysis of Variance, pubmed-meshheading:17912466-Asian Continental Ancestry Group, pubmed-meshheading:17912466-Cell Movement, pubmed-meshheading:17912466-Dyspepsia, pubmed-meshheading:17912466-Female, pubmed-meshheading:17912466-Genetic Predisposition to Disease, pubmed-meshheading:17912466-Genotype, pubmed-meshheading:17912466-Helicobacter Infections, pubmed-meshheading:17912466-Humans, pubmed-meshheading:17912466-Inflammation, pubmed-meshheading:17912466-Interleukin-17, pubmed-meshheading:17912466-Japan, pubmed-meshheading:17912466-Macrophage Migration-Inhibitory Factors, pubmed-meshheading:17912466-Male, pubmed-meshheading:17912466-Polymorphism, Genetic, pubmed-meshheading:17912466-Polymorphism, Single-Stranded Conformational
pubmed:year
2007
pubmed:articleTitle
Genetic polymorphisms of molecules associated with inflammation and immune response in Japanese subjects with functional dyspepsia.
pubmed:affiliation
Department of Gastroenterology, Fujita Health University School of Medicine, Toyoake 470-1192, Japan. tarisawa@fujita-hu.ac.jp
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't