Linked Life Data

17853492

Source:http://linkedlifedata.com/resource/pubmed/id/17853492

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:17853492rdf:typepubmed:Citationlld:pubmed
pubmed-article:17853492lifeskim:mentionsumls-concept:C1333899lld:lifeskim
pubmed-article:17853492lifeskim:mentionsumls-concept:C1704218lld:lifeskim
pubmed-article:17853492lifeskim:mentionsumls-concept:C1704387lld:lifeskim
pubmed-article:17853492lifeskim:mentionsumls-concept:C1522642lld:lifeskim
pubmed-article:17853492lifeskim:mentionsumls-concept:C0019728lld:lifeskim
pubmed-article:17853492lifeskim:mentionsumls-concept:C1704632lld:lifeskim
pubmed-article:17853492lifeskim:mentionsumls-concept:C0871261lld:lifeskim
pubmed-article:17853492lifeskim:mentionsumls-concept:C2911692lld:lifeskim
pubmed-article:17853492lifeskim:mentionsumls-concept:C1706817lld:lifeskim
pubmed-article:17853492lifeskim:mentionsumls-concept:C0439859lld:lifeskim
pubmed-article:17853492lifeskim:mentionsumls-concept:C0368692lld:lifeskim
pubmed-article:17853492pubmed:issue2lld:pubmed
pubmed-article:17853492pubmed:dateCreated2008-1-17lld:pubmed
pubmed-article:17853492pubmed:abstractTextTowards the goal of identifying tumor-rejection antigens on eradicated tumors in bone and soft tissue sarcomas, we evaluated the immune response against antigens presented by lost HLA class I molecules. Tumor specimens and peripheral blood samples were obtained from a 70-year-old woman with pleomorphic malignant fibrous histiocytoma. Over 1-year culture, a tumor cell line (MFH2004) was established. A B-cell line infected with Epstein-Barr virus (B2004-EBV) was developed from the blood samples. HLA genotypes of B2004-EBVcells were A*0206/2402, B*4006/4601, and C*0102/0801, whereas MFH2004 cells were defective for A*0206, B*4006, and C*0102. Loss of HLA-A2 expression was also proved immunohistochemically in the primary tumor tissues. Lost HLA-A2 in MFH2004 cells was retrieved by transfection of HLA-A*0206 cDNA to develop MFH2004-A2. Attempts to induce CTLs by mixed culture with autologous T cells and MFH2004 cells resulted in failure. In contrast, those with MFH2004-A2 induced CTL clones CTL2004-c6 and CTL2004-c17. These CTL clones specifically killed MFH2004-A2 but not MFH2004 or B2004-EBV in an HLA-A2-restricted manner. These findings suggest that CTL2004-c6 and CTL2004-c17 recognize autologous tumor-rejection antigens presented by HLA-A*0206, which may have been expressed by tumor cells that had been eradicated by the host's immunosurveillance system.lld:pubmed
pubmed-article:17853492pubmed:languageenglld:pubmed
pubmed-article:17853492pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17853492pubmed:citationSubsetIMlld:pubmed
pubmed-article:17853492pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17853492pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17853492pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17853492pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17853492pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17853492pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17853492pubmed:statusMEDLINElld:pubmed
pubmed-article:17853492pubmed:monthFeblld:pubmed
pubmed-article:17853492pubmed:issn1554-527Xlld:pubmed
pubmed-article:17853492pubmed:authorpubmed-author:SatoNoriyukiNlld:pubmed
pubmed-article:17853492pubmed:authorpubmed-author:WadaTakuroTlld:pubmed
pubmed-article:17853492pubmed:authorpubmed-author:YamashitaTosh...lld:pubmed
pubmed-article:17853492pubmed:authorpubmed-author:KawaguchiSato...lld:pubmed
pubmed-article:17853492pubmed:authorpubmed-author:IdaKazunoriKlld:pubmed
pubmed-article:17853492pubmed:authorpubmed-author:TorigoeToshih...lld:pubmed
pubmed-article:17853492pubmed:authorpubmed-author:TsukaharaTomo...lld:pubmed
pubmed-article:17853492pubmed:authorpubmed-author:KimuraShigeha...lld:pubmed
pubmed-article:17853492pubmed:authorpubmed-author:MatsumuraTada...lld:pubmed
pubmed-article:17853492pubmed:authorpubmed-author:MuraseMasakiMlld:pubmed
pubmed-article:17853492pubmed:authorpubmed-author:KozakaiYuriko...lld:pubmed
pubmed-article:17853492pubmed:authorpubmed-author:KayaMitunoriMlld:pubmed
pubmed-article:17853492pubmed:copyrightInfo(c) 2007 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.lld:pubmed
pubmed-article:17853492pubmed:issnTypeElectroniclld:pubmed
pubmed-article:17853492pubmed:volume26lld:pubmed
pubmed-article:17853492pubmed:ownerNLMlld:pubmed
pubmed-article:17853492pubmed:authorsCompleteYlld:pubmed
pubmed-article:17853492pubmed:pagination271-8lld:pubmed
pubmed-article:17853492pubmed:dateRevised2011-11-17lld:pubmed
pubmed-article:17853492pubmed:meshHeadingpubmed-meshheading:17853492...lld:pubmed
pubmed-article:17853492pubmed:meshHeadingpubmed-meshheading:17853492...lld:pubmed
pubmed-article:17853492pubmed:meshHeadingpubmed-meshheading:17853492...lld:pubmed
pubmed-article:17853492pubmed:meshHeadingpubmed-meshheading:17853492...lld:pubmed
pubmed-article:17853492pubmed:meshHeadingpubmed-meshheading:17853492...lld:pubmed
pubmed-article:17853492pubmed:meshHeadingpubmed-meshheading:17853492...lld:pubmed
pubmed-article:17853492pubmed:meshHeadingpubmed-meshheading:17853492...lld:pubmed
pubmed-article:17853492pubmed:meshHeadingpubmed-meshheading:17853492...lld:pubmed
pubmed-article:17853492pubmed:meshHeadingpubmed-meshheading:17853492...lld:pubmed
pubmed-article:17853492pubmed:meshHeadingpubmed-meshheading:17853492...lld:pubmed
pubmed-article:17853492pubmed:meshHeadingpubmed-meshheading:17853492...lld:pubmed
pubmed-article:17853492pubmed:meshHeadingpubmed-meshheading:17853492...lld:pubmed
pubmed-article:17853492pubmed:meshHeadingpubmed-meshheading:17853492...lld:pubmed
pubmed-article:17853492pubmed:meshHeadingpubmed-meshheading:17853492...lld:pubmed
pubmed-article:17853492pubmed:meshHeadingpubmed-meshheading:17853492...lld:pubmed
pubmed-article:17853492pubmed:meshHeadingpubmed-meshheading:17853492...lld:pubmed
pubmed-article:17853492pubmed:meshHeadingpubmed-meshheading:17853492...lld:pubmed
pubmed-article:17853492pubmed:year2008lld:pubmed
pubmed-article:17853492pubmed:articleTitleClonal T-cell response against autologous pleomorphic malignant fibrous histiocytoma antigen presented by retrieved HLA-A*0206.lld:pubmed
pubmed-article:17853492pubmed:affiliationDepartment of Orthopaedic Surgery, Sapporo Medical University School of Medicine, Sapporo, 060-8543, Japan.lld:pubmed
pubmed-article:17853492pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:17853492pubmed:publicationTypeCase Reportslld:pubmed
pubmed-article:17853492pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
entrez-gene:3105entrezgene:pubmedpubmed-article:17853492lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:17853492lld:entrezgene
lhgdn:association:33808lhgdn:found_inpubmed-article:17853492lld:lhgdn