|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0018787,
umls-concept:C0027789,
umls-concept:C0043457,
umls-concept:C0185117,
umls-concept:C0243072,
umls-concept:C1171362,
umls-concept:C1280500,
umls-concept:C1333216,
umls-concept:C1515670,
umls-concept:C1519595,
umls-concept:C2263229,
umls-concept:C2350567,
umls-concept:C2911684
|
|
pubmed:issue |
13
|
|
pubmed:dateCreated |
2007-7-19
|
|
pubmed:abstractText |
Folic acid is very important for embryonic development and dihydrofolate reductase is one of the key enzymes in the process of folic acid performing its biological function. Therefore, the dysfunction of dihydrofolate reductase can inhibit the function of folic acid and finally cause the developmental malformations. In this study, we observed the abnormal cardiac phenotypes in dihydrofolate reductase (DHFR) gene knock-down zebrafish embryos, investigated the effect of DHFR on the expression of heart and neural crest derivatives expressed transcript 2 (HAND2) and explored the possible mechanism of DHFR knock-down inducing zebrafish cardiac malformations.
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|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
0366-6999
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
5
|
|
pubmed:volume |
120
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1166-71
|
|
pubmed:meshHeading |
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
Effect of dihydrofolate reductase gene knock-down on the expression of heart and neural crest derivatives expressed transcript 2 in zebrafish cardiac development.
|
|
pubmed:affiliation |
Children's Hospital, Fudan University, Shanghai 200032, China.
|
|
pubmed:publicationType |
Journal Article
|
