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rdf:type |
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lifeskim:mentions |
umls-concept:C0005495,
umls-concept:C0012655,
umls-concept:C0017344,
umls-concept:C0029219,
umls-concept:C0035647,
umls-concept:C0036341,
umls-concept:C0220781,
umls-concept:C0439855,
umls-concept:C1280500,
umls-concept:C1424906,
umls-concept:C1542147
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pubmed:issue |
1
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pubmed:dateCreated |
2007-12-17
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pubmed:abstractText |
The DTNBP1 gene, encoding dysbindin, has been strongly implicated in schizophrenia (SZ) susceptibility by a series of independent genetic association and gene expression studies. Among its known functions, dysbindin is part of a protein complex, termed the biogenesis of lysosome-related organelles complex 1 (BLOC-1), the molecular components of which might be involved in the regulation of vesicular trafficking and dendrite branching.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1873-2402
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pubmed:author |
pubmed-author:BaldwinPatriziaP,
pubmed-author:ClarkeSarahS,
pubmed-author:CorvinAiden PAP,
pubmed-author:CrumlishNiallN,
pubmed-author:DonohoeGaryG,
pubmed-author:GillMichaelM,
pubmed-author:KennyNiamhN,
pubmed-author:McGheeKevin AKA,
pubmed-author:MeagherDavidD,
pubmed-author:MorrisDerek WDW,
pubmed-author:MurphyKevinK,
pubmed-author:NangleJeanne-MarieJM,
pubmed-author:O'CallaghanEadbhardE,
pubmed-author:PurcellShaun MSM,
pubmed-author:QuinnJohnJ,
pubmed-author:SchwaigerSiobhanS,
pubmed-author:ScullyPaulP,
pubmed-author:WaddingtonJohn LJL
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
63
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
24-31
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pubmed:dateRevised |
2008-4-2
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pubmed:meshHeading |
pubmed-meshheading:17618940-Adult,
pubmed-meshheading:17618940-Aged,
pubmed-meshheading:17618940-Biogenesis,
pubmed-meshheading:17618940-Carrier Proteins,
pubmed-meshheading:17618940-Disease Susceptibility,
pubmed-meshheading:17618940-Epistasis, Genetic,
pubmed-meshheading:17618940-Female,
pubmed-meshheading:17618940-Genotype,
pubmed-meshheading:17618940-Humans,
pubmed-meshheading:17618940-Male,
pubmed-meshheading:17618940-Middle Aged,
pubmed-meshheading:17618940-Nerve Tissue Proteins,
pubmed-meshheading:17618940-Polymorphism, Single Nucleotide,
pubmed-meshheading:17618940-Schizophrenia
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pubmed:year |
2008
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pubmed:articleTitle |
Dysbindin (DTNBP1) and the biogenesis of lysosome-related organelles complex 1 (BLOC-1): main and epistatic gene effects are potential contributors to schizophrenia susceptibility.
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pubmed:affiliation |
Neuropsychiatric Genetics Group, Department of Psychiatry and Institute of Molecular Medicine, Trinity College, Dublin, Ireland. morrisdw@tcd.ie/acorvin@tcd.ie
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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