Linked Life Data

17594388

Source:http://linkedlifedata.com/resource/pubmed/id/17594388

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
153
pubmed:dateCreated
2007-6-27
pubmed:abstractText
Although obesity is a key component of type 2 diabetes, particularly in the Western world, many patients are not overweight by traditional criteria. However, evolving definitions of overweight and obesity and an appreciation of the factors influencing obesity in type 2 diabetes are redefining the concept of the non-overweight (lean) patient. Several factors need to be considered, including body mass index, waist circumference and ethnicity when considering whether a patient is lean, and appropriate obesity threshold values need to be used. Lean patients are more likely to be older at diagnosis, possibly have an immune component and may have a tendency towards certain pathophysiological characteristics, notably less insulin resistance and poorer insulin secretory capacity. However, pathophysiological heterogeneity may also be greater among lean patients and this imparts a particular challenge to therapy. An early focus on multiple metabolic defects may provide an optimal approach to treating the lean patient with type 2 diabetes in clinical practice, and combination therapy that addresses both insulin secretory dysfunction and insulin resistance would seem a rational approach.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1368-504X
pubmed:author
pubmed:issnType
Print
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3-9
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
The lean patient with type 2 diabetes: characteristics and therapy challenge.
pubmed:affiliation
Department of Internal Medicine and Endocrine and Metabolic Studies, University of Perugia, Perugia, Italy. brunetti@dimisem.med.unipg.it
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't