| pubmed-article:17584784 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17584784 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:17584784 | lifeskim:mentions | umls-concept:C0006826 | lld:lifeskim |
| pubmed-article:17584784 | lifeskim:mentions | umls-concept:C0205145 | lld:lifeskim |
| pubmed-article:17584784 | lifeskim:mentions | umls-concept:C1101610 | lld:lifeskim |
| pubmed-article:17584784 | lifeskim:mentions | umls-concept:C0017270 | lld:lifeskim |
| pubmed-article:17584784 | lifeskim:mentions | umls-concept:C0332285 | lld:lifeskim |
| pubmed-article:17584784 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:17584784 | lifeskim:mentions | umls-concept:C0752046 | lld:lifeskim |
| pubmed-article:17584784 | lifeskim:mentions | umls-concept:C1521840 | lld:lifeskim |
| pubmed-article:17584784 | pubmed:issue | 13 | lld:pubmed |
| pubmed-article:17584784 | pubmed:dateCreated | 2007-7-27 | lld:pubmed |
| pubmed-article:17584784 | pubmed:abstractText | MicroRNAs (miRNAs) are a class of noncoding small RNAs that regulate gene expression by base pairing with target mRNAs at the 3'-terminal untranslated regions (3'-UTRs), leading to mRNA cleavage or translational repression. Single-nucleotide polymorphisms (SNPs) located at miRNA-binding sites (miRNA-binding SNPs) are likely to affect the expression of the miRNA target and may contribute to the susceptibility of humans to common diseases. We herein performed a genome-wide analysis of SNPs located in the miRNA-binding sites of the 3'-UTR of various human genes. We found that miRNA-binding SNPs are negatively selected in respect to SNP distribution between the miRNA-binding 'seed' sequence and the entire 3'-UTR sequence. Furthermore, we comprehensively defined the expression of each miRNA-binding SNP in cancers versus normal tissues through mining EST databases. Interestingly, we found that some miRNA-binding SNPs exhibit significant different allele frequencies between the human cancer EST libraries and the dbSNP database. More importantly, using human cancer specimens against the dbSNP database for case-control association studies, we found that twelve miRNA-binding SNPs indeed display an aberrant allele frequency in human cancers. Hence, SNPs located in miRNA-binding sites affect miRNA target expression and function, and are potentially associated with cancers. | lld:pubmed |
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| pubmed-article:17584784 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17584784 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17584784 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17584784 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17584784 | pubmed:issn | 1362-4962 | lld:pubmed |
| pubmed-article:17584784 | pubmed:author | pubmed-author:FortinYvesY | lld:pubmed |
| pubmed-article:17584784 | pubmed:author | pubmed-author:LiZhenZ | lld:pubmed |
| pubmed-article:17584784 | pubmed:author | pubmed-author:ShenShi-Hsian... | lld:pubmed |
| pubmed-article:17584784 | pubmed:author | pubmed-author:YuZhenbaoZ | lld:pubmed |
| pubmed-article:17584784 | pubmed:author | pubmed-author:JolicoeurNorm... | lld:pubmed |
| pubmed-article:17584784 | pubmed:author | pubmed-author:WangEdwinE | lld:pubmed |
| pubmed-article:17584784 | pubmed:author | pubmed-author:WuMeiqunM | lld:pubmed |
| pubmed-article:17584784 | pubmed:author | pubmed-author:ZhangLinhuaL | lld:pubmed |
| pubmed-article:17584784 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:17584784 | pubmed:volume | 35 | lld:pubmed |
| pubmed-article:17584784 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17584784 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17584784 | pubmed:pagination | 4535-41 | lld:pubmed |
| pubmed-article:17584784 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:17584784 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17584784 | pubmed:articleTitle | Aberrant allele frequencies of the SNPs located in microRNA target sites are potentially associated with human cancers. | lld:pubmed |
| pubmed-article:17584784 | pubmed:affiliation | Health Sector, Biotechnology Research Institute, National Research Council of Canada, 6100 Royalmount Avenue, Montréal, Québec, Canada. zhenbao.yu@nrc.ca | lld:pubmed |
| pubmed-article:17584784 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17584784 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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