Linked Life Data

17563797

Source:http://linkedlifedata.com/resource/pubmed/id/17563797

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
24
pubmed:dateCreated
2007-6-12
pubmed:abstractText
Asymmetric transfer hydrogenation (ATH) has emerged as a practical, powerful alternative to asymmetric hydrogenation for the production of chiral alcohols, one of the most valuable intermediates in chemical synthesis. In the last a few years, ATH in neat water has proved to be viable, affording chiral alcohols in fast rates, high productivity and high enantioselectivity. The reduction can be carried out with unmodified or tailor-made catalysts by using mild, readily available formate salt as reductant with no organic solvents required, thus providing a simple, economic and green pathway for alcohol production. This Feature Article attempts to present an account of the progress made on aqueous-phase transfer hydrogenation (TH) reactions, with a focus on ATH. The coverage includes a brief background of the chemistry, TH and ATH reactions in water, and the mechanistic aspects of the aqueous-phase reduction.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1359-7345
pubmed:author
pubmed:issnType
Print
pubmed:day
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2449-66
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Aqueous-phase asymmetric transfer hydrogenation of ketones--a greener approach to chiral alcohols.
pubmed:affiliation
Liverpool Centre for Materials and Catalysis, Department of Chemistry, University of Liverpool, Liverpool, UK.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't