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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2007-7-3
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pubmed:abstractText |
NO plays critical roles in vascular function. We show that modulation of the eNOS serine 1179 (S1179) phosphorylation site affects vascular reactivity and determines stroke size in vivo. Transgenic mice expressing only a phosphomimetic (S1179D) form of eNOS show greater vascular reactivity, develop less severe strokes, and have improved cerebral blood flow in a middle cerebral artery occlusion model than mice expressing an unphosphorylatable (S1179A) form. These results provide a molecular mechanism by which multiple diverse cardiovascular risks, such as diabetes and obesity, may be centrally integrated by eNOS phosphorylation in vivo to influence blood flow and cardiovascular disease. They also demonstrate the in vivo relevance of posttranslational modification of eNOS in vascular function.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17557122-10025949,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17557122-10079100,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17557122-10376602,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17557122-10376603,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17557122-10671564,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17557122-10692402,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17557122-10973320,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/17557122-11287317,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17557122-11402048,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17557122-11463332,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17557122-11756337,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17557122-11826287,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17557122-11935063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17557122-11988492,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17557122-12944390,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17557122-12947532,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17557122-15208315,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17557122-15241182,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17557122-15277387,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17557122-15569867,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17557122-15947251,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17557122-16402905,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17557122-16418168,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17557122-16627292,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17557122-7504210,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17557122-7514568,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17557122-7522345,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/17557122-8784243
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0021-9738
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pubmed:author |
pubmed-author:AtochinDmitriy NDN,
pubmed-author:AyataCenkC,
pubmed-author:CritchlowJeffrey DJD,
pubmed-author:DantasAna Paula VAP,
pubmed-author:HuangPaul LPL,
pubmed-author:LiuVictor W TVW,
pubmed-author:Looft-WilsonRobinR,
pubmed-author:MichelThomasT,
pubmed-author:MoskowitzMichael AMA,
pubmed-author:MurataTakahisaT,
pubmed-author:SalomoneSalvatoreS,
pubmed-author:SessaWilliam CWC,
pubmed-author:ShinHwa KyoungHK,
pubmed-author:WangAnnieA
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pubmed:issnType |
Print
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pubmed:volume |
117
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1961-7
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pubmed:dateRevised |
2011-4-12
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pubmed:meshHeading |
pubmed-meshheading:17557122-Alanine,
pubmed-meshheading:17557122-Animals,
pubmed-meshheading:17557122-Aspartic Acid,
pubmed-meshheading:17557122-Brain Ischemia,
pubmed-meshheading:17557122-Cerebral Arteries,
pubmed-meshheading:17557122-Disease Models, Animal,
pubmed-meshheading:17557122-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:17557122-Male,
pubmed-meshheading:17557122-Mice,
pubmed-meshheading:17557122-Mice, Transgenic,
pubmed-meshheading:17557122-Mutation,
pubmed-meshheading:17557122-Nitric Oxide Synthase Type II,
pubmed-meshheading:17557122-Nitric Oxide Synthase Type III,
pubmed-meshheading:17557122-Phosphorylation,
pubmed-meshheading:17557122-Regional Blood Flow,
pubmed-meshheading:17557122-Serine,
pubmed-meshheading:17557122-Stroke
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pubmed:year |
2007
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pubmed:articleTitle |
The phosphorylation state of eNOS modulates vascular reactivity and outcome of cerebral ischemia in vivo.
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pubmed:affiliation |
Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston, MA 02129, USA.
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