To prospectively evaluate the ability of micro-fiberoptic catheters, which simultaneously record white light and near-infrared (NIR) images, to reveal colonic neoplasms after the intravenous administration of activatable "smart" probes that increase in NIR fluorescence subsequent to protease activation.
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Bldg 149, 13th St, Room 5408, Charlestown, MA 02129, USA.