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pubmed-article:17276686pubmed:abstractTextNovel glycerolipidic prodrugs of didanosine and didanosine monophosphate designed to by-pass the hepatic first pass metabolism were synthesized and tested for their cytotoxicity and anti-HIV-1 activity. Formulation as liposomes of dipalmitoylphosphatidylcholine was elaborated. A simple quantitative HPLC-UV method was developed and validated, and ESI-MS was used for qualitative purpose. These two prodrugs exhibited promising biological activities against HIV-1 in in vitro infected cell culture.lld:pubmed
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pubmed-article:17276686pubmed:articleTitleSynthesis and biological evaluation of two glycerolipidic prodrugs of didanosine for direct lymphatic delivery against HIV.lld:pubmed
pubmed-article:17276686pubmed:affiliationUniversité Paris-Sud, UMR CNRS 8612, IFR 141, F-92296 Châtenay-Malabry, France.lld:pubmed
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