Source:http://linkedlifedata.com/resource/pubmed/id/17203225
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2007-1-4
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| pubmed:abstractText |
Beclin 1 is is an autophagy gene, the role of which as a tumour suppressor has recently been recognized in a few studies. We examined the expression of Beclin 1 protein in 212 primary human brain tumours, including 97 high-grade glial tumours, 29 low-grade glial tumours, 4 grade III meningiomas, 19 grade II meningiomas, 52 grade I meningiomas, and 11 medulloblastomas. In 94 cases, including 56 glial tumours, 35 meningiomas, and 3 medulloblastomas we also assessed Beclin 1 mRNA expression by real-time RT-PCR. In most high-grade astrocytic, ependymal neoplasms and atypical meningiomas we found a decrease of cytoplasmic protein expression that was, instead, high in the majority of low-grade tumours and in medulloblastomas. The expression level of Beclin 1 mRNA was significantly lower in glioblastomas than in grade II (p=0.04) and grade I (p=0.01) astrocytomas; in grade III than in grade I astrocytomas (p=0.01); in grade II than in grade I meningiomas (p=0.03); and in all glial tumours when compared to all meningiomas (p<0.0001). Cytoplasmic expression is thought to be linked to the functional protein. Our observations are in line with studies that demonstrated decreased expression of Beclin 1 in human breast, ovarian, prostate and ovarian cancer and furtherly support its involvement also in brain tumours, which had previously been demonstrated in a few experimental studies, both in spontaneous and in therapy-induced autophagy. Furthermore, our study suggests possible differences of Beclin 1 involvement and its role among the different histotypes of brain neoplasms. Further studies are needed to highlight Beclin 1 function in tumour suppression and/or in tumour survival through autophagy and other related programmed cell death processes in brain tumours.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Feb
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| pubmed:issn |
1019-6439
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| pubmed:author |
pubmed-author:CosciElenaE,
pubmed-author:De NisiMaria CaterinaMC,
pubmed-author:FalzaranoSara MSM,
pubmed-author:LuziPietroP,
pubmed-author:MalagninoValeriaV,
pubmed-author:MannucciSusannaS,
pubmed-author:MiraccoCleliaC,
pubmed-author:MonciattiIreneI,
pubmed-author:OliveriGiuseppeG,
pubmed-author:PacentiLorenzoL,
pubmed-author:PirtoliLuigiL,
pubmed-author:ToscanoMarziaM,
pubmed-author:TosiPieroP
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| pubmed:issnType |
Print
|
| pubmed:volume |
30
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
429-36
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| pubmed:meshHeading |
pubmed-meshheading:17203225-Apoptosis Regulatory Proteins,
pubmed-meshheading:17203225-Autophagy,
pubmed-meshheading:17203225-Brain Neoplasms,
pubmed-meshheading:17203225-Cell Nucleus,
pubmed-meshheading:17203225-Cytoplasm,
pubmed-meshheading:17203225-Gene Expression Profiling,
pubmed-meshheading:17203225-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:17203225-Humans,
pubmed-meshheading:17203225-Immunohistochemistry,
pubmed-meshheading:17203225-Medulloblastoma,
pubmed-meshheading:17203225-Membrane Proteins,
pubmed-meshheading:17203225-Meningioma,
pubmed-meshheading:17203225-Oligodendroglioma,
pubmed-meshheading:17203225-RNA, Messenger,
pubmed-meshheading:17203225-Reverse Transcriptase Polymerase Chain Reaction
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| pubmed:year |
2007
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| pubmed:articleTitle |
Protein and mRNA expression of autophagy gene Beclin 1 in human brain tumours.
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| pubmed:affiliation |
Department of Human Pathology and Oncology, Section of Pathological Anatomy, University of Siena, I-53100 Siena, Italy. miracco@unisi.it
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| pubmed:publicationType |
Journal Article
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