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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2007-1-4
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pubmed:abstractText |
The genetic basis of tropical calcific pancreatitis (TCP) is different and is explained by mutations in the pancreatic secretory trypsin inhibitor (SPINK1) gene. However, mutated SPINK1 does not account for the disease in all the patients, neither does it explain the phenotypic heterogeneity between TCP and fibro-calculous pancreatic diabetes (FCPD). Recent studies suggest a crucial role for pancreatic renin-angiotensin system during chronic hypoxia in acute pancreatitis and for angiotensin converting enzyme (ACE) inhibitors in reducing pancreatic fibrosis in experimental models. We investigated the association of ACE gene insertion/deletion (I/D) polymorphism in TCP patients using a case-control approach. Since SPINK1 mutations are proposed a modifier role, we also investigated its interaction with the ACE gene variant.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17163998-10028950,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17163998-10075961,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17163998-10514391,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/17163998-10833490,
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-230X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
42
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:17163998-Adult,
pubmed-meshheading:17163998-Calcinosis,
pubmed-meshheading:17163998-Carrier Proteins,
pubmed-meshheading:17163998-Chromosome Deletion,
pubmed-meshheading:17163998-DNA Mutational Analysis,
pubmed-meshheading:17163998-Diabetes Mellitus,
pubmed-meshheading:17163998-Disease Progression,
pubmed-meshheading:17163998-Electrophoresis, Agar Gel,
pubmed-meshheading:17163998-Female,
pubmed-meshheading:17163998-Fibrosis,
pubmed-meshheading:17163998-Gene Frequency,
pubmed-meshheading:17163998-Genetic Predisposition to Disease,
pubmed-meshheading:17163998-Humans,
pubmed-meshheading:17163998-Male,
pubmed-meshheading:17163998-Mutagenesis, Insertional,
pubmed-meshheading:17163998-Pancreatitis, Chronic,
pubmed-meshheading:17163998-Peptidyl-Dipeptidase A,
pubmed-meshheading:17163998-Phenotype,
pubmed-meshheading:17163998-Polymorphism, Genetic
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pubmed:year |
2006
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pubmed:articleTitle |
Lack of significant association of an insertion/deletion polymorphism in the angiotensin converting enzyme (ACE) gene with tropical calcific pancreatitis.
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pubmed:affiliation |
Genome Research Group, Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500 007, India. seema@ccmb.res.in <seema@ccmb.res.in>
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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