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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2007-2-15
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pubmed:abstractText |
We report three patients with anti-signal recognition particle antibodies who had different presenting clinical pictures, mimicking acute polymyositis, limb-girdle muscular dystrophy, and acute rhabdomyolysis. Muscle biopsies typically showed necrotizing myopathy with little or no inflammation and deposits of membrane attack complex (C5b-9) in endomysial capillaries. The clinical course was severe in two patients and mild in one. The combination of corticosteroid with either an immunosuppressive agent or intravenous immunoglobulins was required to improve the condition of these patients.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0148-639X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
35
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
389-95
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:17143889-Adrenal Cortex Hormones,
pubmed-meshheading:17143889-Adult,
pubmed-meshheading:17143889-Autoantibodies,
pubmed-meshheading:17143889-Biological Markers,
pubmed-meshheading:17143889-Biopsy,
pubmed-meshheading:17143889-Complement Membrane Attack Complex,
pubmed-meshheading:17143889-Diagnosis, Differential,
pubmed-meshheading:17143889-Disease Progression,
pubmed-meshheading:17143889-Female,
pubmed-meshheading:17143889-Humans,
pubmed-meshheading:17143889-Immunosuppressive Agents,
pubmed-meshheading:17143889-Male,
pubmed-meshheading:17143889-Middle Aged,
pubmed-meshheading:17143889-Muscle, Skeletal,
pubmed-meshheading:17143889-Muscle Fibers, Skeletal,
pubmed-meshheading:17143889-Muscular Diseases,
pubmed-meshheading:17143889-Muscular Dystrophies, Limb-Girdle,
pubmed-meshheading:17143889-Phenotype,
pubmed-meshheading:17143889-Polymyositis,
pubmed-meshheading:17143889-Predictive Value of Tests,
pubmed-meshheading:17143889-Rhabdomyolysis,
pubmed-meshheading:17143889-Signal Recognition Particle
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pubmed:year |
2007
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pubmed:articleTitle |
Myopathy associated with anti-signal recognition peptide antibodies: clinical heterogeneity contrasts with stereotyped histopathology.
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pubmed:affiliation |
Centre de Référence des Maladies Neuromusculaires, Service d'Histologie, CHU Henri Mondor, 51 Avenue du Marécal de Lattre de Tassigny, 94010 Créteil, France.
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pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
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