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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2007-1-22
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pubmed:abstractText |
Hydroxylated derivatives were designed and synthesized based on the information of oxidative metabolites. Compounds derived from beta-substituted (2R,3R)-2-amino-3-hydroxypropionic acid showed improved inhibitory activities against the binding of MIP-1alpha to human CCR5, compared with the non-hydroxylated derivatives and the other isomers.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:FukushimaDaikichiD,
pubmed-author:HabashitaHiromuH,
pubmed-author:HisaichiKatsuyaK,
pubmed-author:MaedaKenjiK,
pubmed-author:MatsunagaNaokiN,
pubmed-author:MinamotoChiakiC,
pubmed-author:MitsuyaHiroakiH,
pubmed-author:NishiyamaToshihikoT,
pubmed-author:NishizawaRenaR,
pubmed-author:SagawaKenjiK,
pubmed-author:ShibayamaShiroS,
pubmed-author:TadaHideakiH,
pubmed-author:TakaokaYoshikazuY,
pubmed-author:TodaMasaakiM
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
727-31
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:17118654-Animals,
pubmed-meshheading:17118654-Anti-HIV Agents,
pubmed-meshheading:17118654-CHO Cells,
pubmed-meshheading:17118654-Chemokine CCL3,
pubmed-meshheading:17118654-Chemokine CCL4,
pubmed-meshheading:17118654-Chromatography, High Pressure Liquid,
pubmed-meshheading:17118654-Combinatorial Chemistry Techniques,
pubmed-meshheading:17118654-Cricetinae,
pubmed-meshheading:17118654-Cricetulus,
pubmed-meshheading:17118654-Drug Design,
pubmed-meshheading:17118654-Humans,
pubmed-meshheading:17118654-Hydroxylation,
pubmed-meshheading:17118654-Indicators and Reagents,
pubmed-meshheading:17118654-Isomerism,
pubmed-meshheading:17118654-Macrophage Inflammatory Proteins,
pubmed-meshheading:17118654-Magnetic Resonance Spectroscopy,
pubmed-meshheading:17118654-Microsomes, Liver,
pubmed-meshheading:17118654-Oxidation-Reduction,
pubmed-meshheading:17118654-Protein Binding,
pubmed-meshheading:17118654-Rats,
pubmed-meshheading:17118654-Receptors, CCR5
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pubmed:year |
2007
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pubmed:articleTitle |
Spirodiketopiperazine-based CCR5 antagonists: Lead optimization from biologically active metabolite.
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pubmed:affiliation |
Medicinal Chemistry Research Laboratories, Ono Pharmaceutical Co., Ltd, Osaka 618-8585, Japan. r.nishizawa@ono.co.jp
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pubmed:publicationType |
Journal Article,
In Vitro
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