Source:http://linkedlifedata.com/resource/pubmed/id/16965818
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
|
| pubmed:dateCreated |
2006-10-18
|
| pubmed:abstractText |
Reaction of the vitamin K(3) derivative menadione sodium bisulfite thiosemicarbazone (NaK(3)TSC) with chloro(triethylphosphine)gold(I) afforded the complex [AuPEt(3)(K(3)TSC)]. This compound consists of discrete molecules in which the metal is almost linearly coordinated to P and S. Preliminary in vitro screening showed significant anti-cancer activity, notably against the cisplatin-resistant cell line A2780cis.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0162-0134
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
100
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1858-60
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| pubmed:meshHeading |
pubmed-meshheading:16965818-Cell Line, Tumor,
pubmed-meshheading:16965818-Cisplatin,
pubmed-meshheading:16965818-Drug Resistance, Neoplasm,
pubmed-meshheading:16965818-Drug Screening Assays, Antitumor,
pubmed-meshheading:16965818-Humans,
pubmed-meshheading:16965818-Hydrogen Bonding,
pubmed-meshheading:16965818-Inhibitory Concentration 50,
pubmed-meshheading:16965818-Molecular Structure,
pubmed-meshheading:16965818-Organogold Compounds,
pubmed-meshheading:16965818-Vitamin K 3
|
| pubmed:year |
2006
|
| pubmed:articleTitle |
A gold(I) complex with a vitamin K3 derivative: characterization and antitumoral activity.
|
| pubmed:affiliation |
Departamento de Química Inorgánica, Facultade de Farmacia, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Galicia, Spain. qiscasas@usc.es <qiscasas@usc.es>
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|