Linked Life Data

1684378

Source:http://linkedlifedata.com/resource/pubmed/id/1684378

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1992-1-24
pubmed:abstractText
A number of restriction fragment length polymorphisms (RFLPs) of the apolipoprotein B (apoB) and apolipoprotein A-I/C-III(apoA-I/C-III) genes have been found to be associated with serum lipoprotein levels in many adult populations. In order to examine whether these genetic polymorphisms influence serum lipoprotein levels in childhood and adolescence, we determined the apoB XbaI and apoA-I/C-III SstI genotypes and serum lipoprotein concentrations in 307 healthy Finns aged 9 to 21 years. In the age groups of 9, 12, and 15 years, subjects homozygous for the X2 allele (the XbaI site present) of the apoB gene had mean serum low-density lipoprotein (LDL) cholesterol levels (3.69, 3.43, and 3.15 mmol/l, respectively) that were 12-20% higher than those in subjects homozygous for the absence of this allele (3.08, 3.02, and 2.80 mmol/l, respectively). This association was more significant in males than in females. At the age of 9 to 18 years, subjects carrying the S2 allele (SstI site present) of the apoA-I/C-III gene complex had an approximately 6-15% higher mean serum LDL-cholesterol level than those homozygous for its absence. The combined genotype X2+S2+ (the simultaneous presence of the X2 allele and the S2 allele) was associated with an even more marked elevation of serum LDL-cholesterol level than either allele alone. As an example, the serum LDL cholesterol concentration was 20% higher in 9-year-old subjects with at least one X2 and one S2 allele than in those without either allele (3.55 vs. 2.97 mmol/l, P less than 0.005). The S2 allele was found to be significantly more frequent in eastern than in western Finland, whereas no significant areal differences were seen in the occurrence of the X2 allele. In conclusion, genetic variations of the apoB and apoA-I/C-III gene loci influence serum lipoprotein concentrations already in childhood.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0022-2275
pubmed:author
pubmed:issnType
Print
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1477-87
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:1684378-Adolescent, pubmed-meshheading:1684378-Adult, pubmed-meshheading:1684378-Age Factors, pubmed-meshheading:1684378-Alleles, pubmed-meshheading:1684378-Apolipoprotein A-I, pubmed-meshheading:1684378-Apolipoprotein C-III, pubmed-meshheading:1684378-Apolipoproteins B, pubmed-meshheading:1684378-Apolipoproteins C, pubmed-meshheading:1684378-Child, pubmed-meshheading:1684378-Cholesterol, pubmed-meshheading:1684378-Cholesterol, HDL, pubmed-meshheading:1684378-Cholesterol, LDL, pubmed-meshheading:1684378-DNA, pubmed-meshheading:1684378-Female, pubmed-meshheading:1684378-Finland, pubmed-meshheading:1684378-Genotype, pubmed-meshheading:1684378-Humans, pubmed-meshheading:1684378-Male, pubmed-meshheading:1684378-Polymorphism, Restriction Fragment Length, pubmed-meshheading:1684378-Triglycerides
pubmed:year
1991
pubmed:articleTitle
DNA polymorphisms of the apolipoprotein B and A-I/C-III genes are associated with variations of serum low density lipoprotein cholesterol level in childhood.
pubmed:affiliation
Institute of Biotechnology, University of Helsinki, Finland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't