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rdf:type |
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lifeskim:mentions |
umls-concept:C0011209,
umls-concept:C0013443,
umls-concept:C0018557,
umls-concept:C0023828,
umls-concept:C0026336,
umls-concept:C0026339,
umls-concept:C0060389,
umls-concept:C0230171,
umls-concept:C0333562,
umls-concept:C0439682,
umls-concept:C1515655,
umls-concept:C1533691,
umls-concept:C1627358,
umls-concept:C1720782,
umls-concept:C2349975,
umls-concept:C2603343
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pubmed:issue |
1-2
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pubmed:dateCreated |
2006-9-25
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pubmed:abstractText |
Finasteride is indicated orally in the treatment of androgenetic alopecia and some other pilosebaceous unit (PSU) disorders. We wished to investigate whether topical application of finasteride-containing vesicles (liposomes and niosomes) could enhance drug concentration at the PSU, as compared to finasteride hydroalcoholic solution (HA). Liposomes consisted of phospholipid (dimyristoyl phosphatidylcholine (DMPC) or egg lecithin):cholesterol:dicetylphosphate (8:2:1, mole ratio). Niosomes were comprising non-ionic surfactant (polyoxyethylene alkyl ethers (Brij series) or sorbitan monopalmitate):cholesterol:dicetylphosphate (7:3:1, mole ratio). Vesicles were prepared by the film hydration technique and characterized with regard to the size, drug entrapment efficiency and gel-liquid transition temperature (T(c)). In vitro permeation of (3)H-finasteride through hamster flank skin was faster from hydroalcoholic solution (0.13 microg/cm(2)h) compared to vesicles (0.025-0.058 microg/cm(2)h). In vivo deposition of (3)H-finasteride vesicles in hamster ear showed that liquid-state vesicle, i.e. those made of DMPC or Brij97:Brij76 (1:1), were able to deposit 2.1 or 2.3% of the applied dose to the PSU, respectively. This was significantly higher than drug deposition by gel-state vesicles (0.35-0.51%) or HA (0.76%). Both in vitro permeation and in vivo deposition studies, demonstrated the potentials of liquid-state liposomes and niosomes for successful delivery of finasteride to the PSU.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol,
http://linkedlifedata.com/resource/pubmed/chemical/Drug Carriers,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Finasteride,
http://linkedlifedata.com/resource/pubmed/chemical/Liposomes,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylcholines,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoric Acid Esters,
http://linkedlifedata.com/resource/pubmed/chemical/Plant Oils,
http://linkedlifedata.com/resource/pubmed/chemical/Polyethylene Glycols,
http://linkedlifedata.com/resource/pubmed/chemical/dicetylphosphate,
http://linkedlifedata.com/resource/pubmed/chemical/polyethylene glycol oleyl ether
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0378-5173
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
12
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pubmed:volume |
323
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1-10
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pubmed:meshHeading |
pubmed-meshheading:16837150-Administration, Cutaneous,
pubmed-meshheading:16837150-Animals,
pubmed-meshheading:16837150-Cholesterol,
pubmed-meshheading:16837150-Cricetinae,
pubmed-meshheading:16837150-Drug Carriers,
pubmed-meshheading:16837150-Drug Delivery Systems,
pubmed-meshheading:16837150-Ear, External,
pubmed-meshheading:16837150-Enzyme Inhibitors,
pubmed-meshheading:16837150-Finasteride,
pubmed-meshheading:16837150-Liposomes,
pubmed-meshheading:16837150-Male,
pubmed-meshheading:16837150-Mesocricetus,
pubmed-meshheading:16837150-Particle Size,
pubmed-meshheading:16837150-Phosphatidylcholines,
pubmed-meshheading:16837150-Phosphoric Acid Esters,
pubmed-meshheading:16837150-Plant Oils,
pubmed-meshheading:16837150-Polyethylene Glycols,
pubmed-meshheading:16837150-Skin,
pubmed-meshheading:16837150-Skin Absorption
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pubmed:year |
2006
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pubmed:articleTitle |
Enhancement of follicular delivery of finasteride by liposomes and niosomes 1. In vitro permeation and in vivo deposition studies using hamster flank and ear models.
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pubmed:affiliation |
Department of Pharmaceutics, School of Pharmacy and Isfahan Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. tabbakhian@pharm.mui.ac.ir
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pubmed:publicationType |
Journal Article
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