| pubmed-article:16772287 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16772287 | lifeskim:mentions | umls-concept:C0029419 | lld:lifeskim |
| pubmed-article:16772287 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:16772287 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:16772287 | lifeskim:mentions | umls-concept:C1156210 | lld:lifeskim |
| pubmed-article:16772287 | lifeskim:mentions | umls-concept:C0271510 | lld:lifeskim |
| pubmed-article:16772287 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:16772287 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:16772287 | lifeskim:mentions | umls-concept:C1335840 | lld:lifeskim |
| pubmed-article:16772287 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:16772287 | lifeskim:mentions | umls-concept:C1548534 | lld:lifeskim |
| pubmed-article:16772287 | pubmed:issue | 32 | lld:pubmed |
| pubmed-article:16772287 | pubmed:dateCreated | 2006-8-7 | lld:pubmed |
| pubmed-article:16772287 | pubmed:abstractText | Tissue-specific activation of the osteocalcin (OC) gene is associated with changes in chromatin structure at the promoter region. Two nuclease-hypersensitive sites span the key regulatory elements that control basal tissue-specific and vitamin D3-enhanced OC gene transcription. To gain understanding of the molecular mechanisms involved in chromatin remodeling of the OC gene, we have examined the requirement for SWI/SNF activity. We inducibly expressed an ATPase-defective BRG1 catalytic subunit that forms inactive SWI/SNF complexes that bind to the OC promoter. This interaction results in inhibition of both basal and vitamin D3-enhanced OC gene transcription and a marked decrease in nuclease hypersensitivity. We find that SWI/SNF is recruited to the OC promoter via the transcription factor CCAAT/enhancer-binding protein beta, which together with Runx2 forms a stable complex to facilitate RNA polymerase II binding and activation of OC gene transcription. Together, our results indicate that the SWI/SNF complex is a key regulator of the chromatin-remodeling events that promote tissue-specific transcription in osteoblasts. | lld:pubmed |
| pubmed-article:16772287 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16772287 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16772287 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16772287 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16772287 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16772287 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16772287 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16772287 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16772287 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16772287 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:16772287 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:16772287 | pubmed:author | pubmed-author:MontecinoMart... | lld:pubmed |
| pubmed-article:16772287 | pubmed:author | pubmed-author:SteinGary SGS | lld:pubmed |
| pubmed-article:16772287 | pubmed:author | pubmed-author:SteinJanet... | lld:pubmed |
| pubmed-article:16772287 | pubmed:author | pubmed-author:LianJane BJB | lld:pubmed |
| pubmed-article:16772287 | pubmed:author | pubmed-author:van... | lld:pubmed |
| pubmed-article:16772287 | pubmed:author | pubmed-author:ImbalzanoAnth... | lld:pubmed |
| pubmed-article:16772287 | pubmed:author | pubmed-author:VillagraAleja... | lld:pubmed |
| pubmed-article:16772287 | pubmed:author | pubmed-author:ParedesRobert... | lld:pubmed |
| pubmed-article:16772287 | pubmed:author | pubmed-author:OlateJuanJ | lld:pubmed |
| pubmed-article:16772287 | pubmed:author | pubmed-author:CruzatFernand... | lld:pubmed |
| pubmed-article:16772287 | pubmed:author | pubmed-author:CarvalloLoret... | lld:pubmed |
| pubmed-article:16772287 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16772287 | pubmed:day | 11 | lld:pubmed |
| pubmed-article:16772287 | pubmed:volume | 281 | lld:pubmed |
| pubmed-article:16772287 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16772287 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16772287 | pubmed:pagination | 22695-706 | lld:pubmed |
| pubmed-article:16772287 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:16772287 | pubmed:meshHeading | pubmed-meshheading:16772287... | lld:pubmed |
| pubmed-article:16772287 | pubmed:meshHeading | pubmed-meshheading:16772287... | lld:pubmed |
| pubmed-article:16772287 | pubmed:meshHeading | pubmed-meshheading:16772287... | lld:pubmed |
| pubmed-article:16772287 | pubmed:meshHeading | pubmed-meshheading:16772287... | lld:pubmed |
| pubmed-article:16772287 | pubmed:meshHeading | pubmed-meshheading:16772287... | lld:pubmed |
| pubmed-article:16772287 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16772287 | pubmed:articleTitle | Chromatin remodeling and transcriptional activity of the bone-specific osteocalcin gene require CCAAT/enhancer-binding protein beta-dependent recruitment of SWI/SNF activity. | lld:pubmed |
| pubmed-article:16772287 | pubmed:affiliation | Departamento de Bioquimica y Biologia Molecular, Facultad de Ciencias Biologicas, Universidad de Concepcion, Casilla 160-C, 4079100 Concepcion, Chile. | lld:pubmed |
| pubmed-article:16772287 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16772287 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16772287 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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