Linked Life Data

16709873

Source:http://linkedlifedata.com/resource/pubmed/id/16709873

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pubmed-article:16709873pubmed:abstractTextTonsillar infection with Streptococcus pyogenes may induce several nonsuppurative autoimmune sequelae. The precise pathogenetic mechanisms behind this clinically well-established association are still unresolved. Using TCR analysis, we sought to identify a link between streptococcal tonsillitis and the T cell-mediated autoimmune response in psoriasis. Three patients with streptococcal-induced psoriasis underwent tonsillectomy. Using size spectratyping and sequencing of TCR beta-chain variable region gene (TCRBV) rearrangements, we compared the TCR usage of psoriatic skin lesions, blood, tonsils, and tonsillar T cells fractionated according to the expression of the skin address in "cutaneous lymphocyte-associated Ag" (CLA). TCRBV-size spectratype analysis of the blood lymphocytes, tonsils, and the CLA-negative tonsillar T cells revealed largely unselected T cell populations. Instead, TCRBV gene families of the psoriatic lesions and skin-homing CLA-positive tonsillar T cells displayed highly restricted spectratypes. Sequencing of TCRBV cDNA identified various clonal TCRBV rearrangements within the psoriatic lesions that indicated Ag-driven T cell expansion. Several of these clonotypes were also detected within the tonsils and, in one of the patients, within the small subset of CLA-positive tonsillar T cells, suggesting that T cells from the same T cell clones were simultaneously present within skin and tonsillar tissue. Because after tonsillectomy psoriasis cleared in all three patients our observations indicate that T cells may connect psoriatic inflammation to streptococcal angina. They suggest that the chronic streptococcal immune stimulus within the tonsils could act as a source for pathogenic T cells in poststreptococcal disorders, and they may help to explain why eliminating this source with tonsillectomy may improve streptococcal-induced sequelae.lld:pubmed
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pubmed-article:16709873pubmed:dateRevised2010-11-18lld:pubmed
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pubmed-article:16709873pubmed:articleTitleIdentical TCR beta-chain rearrangements in streptococcal angina and skin lesions of patients with psoriasis vulgaris.lld:pubmed
pubmed-article:16709873pubmed:affiliationDepartment of Dermatology, Ludwig-Maximilians-University of Munich, Munich, Germany.lld:pubmed
pubmed-article:16709873pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:16709873pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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