Source:http://linkedlifedata.com/resource/pubmed/id/16709873
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
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| pubmed:dateCreated |
2006-5-19
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| pubmed:abstractText |
Tonsillar infection with Streptococcus pyogenes may induce several nonsuppurative autoimmune sequelae. The precise pathogenetic mechanisms behind this clinically well-established association are still unresolved. Using TCR analysis, we sought to identify a link between streptococcal tonsillitis and the T cell-mediated autoimmune response in psoriasis. Three patients with streptococcal-induced psoriasis underwent tonsillectomy. Using size spectratyping and sequencing of TCR beta-chain variable region gene (TCRBV) rearrangements, we compared the TCR usage of psoriatic skin lesions, blood, tonsils, and tonsillar T cells fractionated according to the expression of the skin address in "cutaneous lymphocyte-associated Ag" (CLA). TCRBV-size spectratype analysis of the blood lymphocytes, tonsils, and the CLA-negative tonsillar T cells revealed largely unselected T cell populations. Instead, TCRBV gene families of the psoriatic lesions and skin-homing CLA-positive tonsillar T cells displayed highly restricted spectratypes. Sequencing of TCRBV cDNA identified various clonal TCRBV rearrangements within the psoriatic lesions that indicated Ag-driven T cell expansion. Several of these clonotypes were also detected within the tonsils and, in one of the patients, within the small subset of CLA-positive tonsillar T cells, suggesting that T cells from the same T cell clones were simultaneously present within skin and tonsillar tissue. Because after tonsillectomy psoriasis cleared in all three patients our observations indicate that T cells may connect psoriatic inflammation to streptococcal angina. They suggest that the chronic streptococcal immune stimulus within the tonsils could act as a source for pathogenic T cells in poststreptococcal disorders, and they may help to explain why eliminating this source with tonsillectomy may improve streptococcal-induced sequelae.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/CTAGE1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Lymphocyte Homing
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jun
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| pubmed:issn |
0022-1767
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:day |
1
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| pubmed:volume |
176
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
7104-11
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| pubmed:dateRevised |
2010-11-18
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| pubmed:meshHeading |
pubmed-meshheading:16709873-Adult,
pubmed-meshheading:16709873-Amino Acid Sequence,
pubmed-meshheading:16709873-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:16709873-Antigens, Neoplasm,
pubmed-meshheading:16709873-Base Sequence,
pubmed-meshheading:16709873-Clone Cells,
pubmed-meshheading:16709873-Gene Rearrangement, beta-Chain T-Cell Antigen Receptor,
pubmed-meshheading:16709873-Humans,
pubmed-meshheading:16709873-Membrane Glycoproteins,
pubmed-meshheading:16709873-Molecular Sequence Data,
pubmed-meshheading:16709873-Multigene Family,
pubmed-meshheading:16709873-Palatine Tonsil,
pubmed-meshheading:16709873-Psoriasis,
pubmed-meshheading:16709873-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:16709873-Receptors, Lymphocyte Homing,
pubmed-meshheading:16709873-Remission Induction,
pubmed-meshheading:16709873-Rheumatic Heart Disease,
pubmed-meshheading:16709873-Severity of Illness Index,
pubmed-meshheading:16709873-Streptococcal Infections,
pubmed-meshheading:16709873-Streptococcus pyogenes,
pubmed-meshheading:16709873-T-Lymphocyte Subsets,
pubmed-meshheading:16709873-Tonsillectomy,
pubmed-meshheading:16709873-Tonsillitis
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| pubmed:year |
2006
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| pubmed:articleTitle |
Identical TCR beta-chain rearrangements in streptococcal angina and skin lesions of patients with psoriasis vulgaris.
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| pubmed:affiliation |
Department of Dermatology, Ludwig-Maximilians-University of Munich, Munich, Germany.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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