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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
15
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pubmed:dateCreated |
2006-4-12
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pubmed:abstractText |
Administration of daclizumab, a humanized mAb directed against the IL-2Ralpha chain, strongly reduces brain inflammation in multiple sclerosis patients. Here we show that daclizumab treatment leads to only a mild functional blockade of CD4(+) T cells, the major candidate in multiple sclerosis pathogenesis. Instead, daclizumab therapy was associated with a gradual decline in circulating CD4(+) and CD8(+) T cells and significant expansion of CD56(bright) natural killer (NK) cells in vivo, and this effect correlated highly with the treatment response. In vitro studies showed that NK cells inhibited T cell survival in activated peripheral blood mononuclear cell cultures by a contact-dependent mechanism. Positive correlations between expansion of CD56(bright) NK cells and contraction of CD4(+) and CD8(+) T cell numbers in individual patients in vivo provides supporting evidence for NK cell-mediated negative immunoregulation of activated T cells during daclizumab therapy. Our data support the existence of an immunoregulatory pathway wherein activated CD56(bright) NK cells inhibit T cell survival. This immunoregulation has potential importance for the treatment of autoimmune diseases and transplant rejection and toward modification of tumor immunity.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16585503-10377437,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16585503-10415039,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16585503-11063837,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16585503-11102772,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16585503-11342442,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16585503-11505971,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16585503-11525803,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16585503-11698225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16585503-11998892,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16585503-12124859,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16585503-12480696,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16585503-12640450,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16585503-12646619,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16585503-14500636,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16585503-14599854,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16585503-15067033,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16585503-15161974,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16585503-15604218,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16585503-15753206,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16585503-1692080,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16585503-1716974,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16585503-2513570,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16585503-7489743,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16585503-7523571,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16585503-8159750,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16585503-8176234,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16585503-8235625,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16585503-9362528,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16585503-9505189,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16585503-9723424,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16585503-9794841,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16585503-9851439
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal, Humanized,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD56,
http://linkedlifedata.com/resource/pubmed/chemical/IL2RA protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Il2ra protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Immunosuppressive Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2 Receptor alpha Subunit,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/daclizumab
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
11
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pubmed:volume |
103
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5941-6
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:16585503-Animals,
pubmed-meshheading:16585503-Antibodies, Monoclonal,
pubmed-meshheading:16585503-Antibodies, Monoclonal, Humanized,
pubmed-meshheading:16585503-Antigens, CD,
pubmed-meshheading:16585503-Antigens, CD56,
pubmed-meshheading:16585503-Disease Models, Animal,
pubmed-meshheading:16585503-Humans,
pubmed-meshheading:16585503-Immunoglobulin G,
pubmed-meshheading:16585503-Immunosuppressive Agents,
pubmed-meshheading:16585503-Inflammation,
pubmed-meshheading:16585503-Interleukin-2,
pubmed-meshheading:16585503-Interleukin-2 Receptor alpha Subunit,
pubmed-meshheading:16585503-Killer Cells, Natural,
pubmed-meshheading:16585503-Lymphocyte Activation,
pubmed-meshheading:16585503-Lymphocyte Subsets,
pubmed-meshheading:16585503-Mice,
pubmed-meshheading:16585503-Mice, Knockout,
pubmed-meshheading:16585503-Multiple Sclerosis,
pubmed-meshheading:16585503-Receptors, Interleukin-2,
pubmed-meshheading:16585503-T-Lymphocytes
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pubmed:year |
2006
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