| pubmed-article:1656210 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1656210 | lifeskim:mentions | umls-concept:C0006675 | lld:lifeskim |
| pubmed-article:1656210 | lifeskim:mentions | umls-concept:C0024660 | lld:lifeskim |
| pubmed-article:1656210 | lifeskim:mentions | umls-concept:C0027061 | lld:lifeskim |
| pubmed-article:1656210 | lifeskim:mentions | umls-concept:C0026820 | lld:lifeskim |
| pubmed-article:1656210 | lifeskim:mentions | umls-concept:C1821417 | lld:lifeskim |
| pubmed-article:1656210 | lifeskim:mentions | umls-concept:C0175659 | lld:lifeskim |
| pubmed-article:1656210 | lifeskim:mentions | umls-concept:C0349674 | lld:lifeskim |
| pubmed-article:1656210 | lifeskim:mentions | umls-concept:C1516240 | lld:lifeskim |
| pubmed-article:1656210 | lifeskim:mentions | umls-concept:C1998811 | lld:lifeskim |
| pubmed-article:1656210 | lifeskim:mentions | umls-concept:C0222045 | lld:lifeskim |
| pubmed-article:1656210 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:1656210 | pubmed:dateCreated | 1991-11-7 | lld:pubmed |
| pubmed-article:1656210 | pubmed:abstractText | The purpose of this study was to determine if selected biochemical parameters representing the contractile and calcium regulating systems of cardiac muscle scaled among mammals having inherently different resting heart rates (RHR). Eight mammalian species with RHR ranging from 51 to 475 beats per minute (bpm) were studied. The oxidative capacity of the myocardium is highly correlated with the RHR. The hypothesis of the present study was that the capacities of the energy utilizing processes of contraction and calcium regulation would also be correlated to the functional demand imposed on the muscle as represented by the RHR. Myosin (M) and myofibrillar (MF) ATPase activities, myosin isoenzyme distribution and sarcoplasmic reticulum (SR) ATPase activity were determined. Animals with RHR above 300 bpm express V1 myosin while animals with lower RHR express primarily V3. M and MF ATPase activities correlated with RHR, but the major difference in activities occurred at the 'threshold' RHR of about 300 bpm at which the switch from V3 to V1 appears to occur. SR ATPase activity per mg of microsomal protein was for the most part constant among different mammals, but the SR ATPase activity per g of heart tissue was significantly correlated with RHR as slower beating hearts tended to yield less SR protein per unit mass. We conclude that both the contractile and calcium regulating systems are scaled to the functional parameter of RHR among different mammals. The contractile system uses a slow myosin ATPase isoform at low resting heart rates whereas above the postulated threshold RHR of about 300 bpm a switch in gene expression to a fast myosin ATPase isoform occurs.(ABSTRACT TRUNCATED AT 250 WORDS) | lld:pubmed |
| pubmed-article:1656210 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1656210 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1656210 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1656210 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1656210 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1656210 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1656210 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1656210 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1656210 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:1656210 | pubmed:issn | 0300-8177 | lld:pubmed |
| pubmed-article:1656210 | pubmed:author | pubmed-author:IanuzzoC DCD | lld:pubmed |
| pubmed-article:1656210 | pubmed:author | pubmed-author:HamiltonNN | lld:pubmed |
| pubmed-article:1656210 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1656210 | pubmed:day | 14 | lld:pubmed |
| pubmed-article:1656210 | pubmed:volume | 106 | lld:pubmed |
| pubmed-article:1656210 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1656210 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1656210 | pubmed:pagination | 133-41 | lld:pubmed |
| pubmed-article:1656210 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:1656210 | pubmed:meshHeading | pubmed-meshheading:1656210-... | lld:pubmed |
| pubmed-article:1656210 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1656210 | pubmed:articleTitle | Contractile and calcium regulating capacities of myocardia of different sized mammals scale with resting heart rate. | lld:pubmed |
| pubmed-article:1656210 | pubmed:affiliation | Department of Physical Education, York University, Toronto, ON, Canada. | lld:pubmed |
| pubmed-article:1656210 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1656210 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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