| pubmed-article:16555281 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16555281 | lifeskim:mentions | umls-concept:C1258014 | lld:lifeskim |
| pubmed-article:16555281 | lifeskim:mentions | umls-concept:C0238689 | lld:lifeskim |
| pubmed-article:16555281 | lifeskim:mentions | umls-concept:C0080194 | lld:lifeskim |
| pubmed-article:16555281 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:16555281 | lifeskim:mentions | umls-concept:C0242960 | lld:lifeskim |
| pubmed-article:16555281 | lifeskim:mentions | umls-concept:C0036639 | lld:lifeskim |
| pubmed-article:16555281 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:16555281 | pubmed:dateCreated | 2006-3-28 | lld:pubmed |
| pubmed-article:16555281 | pubmed:abstractText | Human metapneumovirus (hMPV) is a newly identified paramixovirus, associated with respiratory illnesses in all age groups. Two genetic groups of hMPV have been described. The nucleotide sequences of the G and F genes from 11 Argentinean hMPV strains (1998-2003) were determined by RT-PCR and direct sequencing. Phylogenetic analysis showed that hMPV strains clustered into two main genetic lineages, A and B. Strains clustered into A group were split into two sublineages, A1 and A2. All strains belonging to group B clustered with representative strains from sublineage B1. No Argentinean strains belonged to sublineage B2. F sequences showed high percentage identities at nucleotide and amino acid levels. In contrast, G sequences showed high diversity between A and B groups. Most changes observed in the deduced G protein sequence were amino acid substitutions in the extracellular domain, and changes in stop codon usage leading to different lengths in the G proteins. High content of serine and threonine residues were also shown, suggesting that this protein would be highly glycosylated. The potential sites for N- and O-glycosylation seem to have a different conservation pattern between the two main groups. This is the first report on the genetic variability of the G and F protein genes of hMPV strains in South America. Two main genetic groups and at least three subgroups were revealed among Argentinean hMPV strains. The F protein seems to be highly conserved, whereas the G protein showed extensive diversity between groups A and B. | lld:pubmed |
| pubmed-article:16555281 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16555281 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16555281 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16555281 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16555281 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16555281 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16555281 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16555281 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16555281 | pubmed:month | May | lld:pubmed |
| pubmed-article:16555281 | pubmed:issn | 0146-6615 | lld:pubmed |
| pubmed-article:16555281 | pubmed:author | pubmed-author:CarballalGuad... | lld:pubmed |
| pubmed-article:16555281 | pubmed:author | pubmed-author:VidelaCristin... | lld:pubmed |
| pubmed-article:16555281 | pubmed:author | pubmed-author:TrentoAlfonsi... | lld:pubmed |
| pubmed-article:16555281 | pubmed:author | pubmed-author:GalianoMonica... | lld:pubmed |
| pubmed-article:16555281 | pubmed:author | pubmed-author:VerLorenaL | lld:pubmed |
| pubmed-article:16555281 | pubmed:copyrightInfo | Copyright 2006 Wiley-Liss, Inc. | lld:pubmed |
| pubmed-article:16555281 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16555281 | pubmed:volume | 78 | lld:pubmed |
| pubmed-article:16555281 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16555281 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16555281 | pubmed:pagination | 631-7 | lld:pubmed |
| pubmed-article:16555281 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:16555281 | pubmed:meshHeading | pubmed-meshheading:16555281... | lld:pubmed |
| pubmed-article:16555281 | pubmed:meshHeading | pubmed-meshheading:16555281... | lld:pubmed |
| pubmed-article:16555281 | pubmed:meshHeading | pubmed-meshheading:16555281... | lld:pubmed |
| pubmed-article:16555281 | pubmed:meshHeading | pubmed-meshheading:16555281... | lld:pubmed |
| pubmed-article:16555281 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16555281 | pubmed:articleTitle | Genetic heterogeneity of G and F protein genes from Argentinean human metapneumovirus strains. | lld:pubmed |
| pubmed-article:16555281 | pubmed:affiliation | Laboratorio de Virología Clínica, Centro de Educación Médica e Investigaciones Clínicas, CEMIC, Hospital Universitario, Buenos Aires, Argentina. | lld:pubmed |
| pubmed-article:16555281 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16555281 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| family:PF09595.5 | family:pubmed | pubmed-article:16555281 | lld:pfam |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16555281 | lld:pubmed |
