Linked Life Data

16536353

Source:http://linkedlifedata.com/resource/pubmed/id/16536353

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2006-3-15
pubmed:abstractText
Preclinical models, if used appropriately, can greatly accelerate the understanding of neuropsychiatric disorders. A number of animal models have predictive validity for antidopaminergic compounds that have traditionally been used to suppress motor and vocal tics in TS. Other models have been proposed that may have construct validity for specific hypotheses of infectious/immune and neural circuit etiologies of TS. A more comprehensive set of models is described, based on the hypothesis that primary symptoms of TS, including sensory tics and premonitory urges, result from dysfunction in brain mechanisms that regulate sensorimotor gating. These models utilize operational measures of central gating mechanisms, including PPI of the startle reflex, to achieve predictive validity across a number of different chemical classes of drugs, and to achieve construct validity across broad domains of neurodevelopmental, immune and genetic etiologies of TS. PPI-based animal models offer a number of strong advantages for predictive and mechanistic studies of TS. Ultimately, the utility of these "deficient gating" models will be judged by their ability to bring us closer to identifying the causes and effective treatments of this disorder.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0091-3952
pubmed:author
pubmed:issnType
Print
pubmed:volume
99
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
69-88
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Preclinical models relevant to Tourette syndrome.
pubmed:affiliation
Department of Psychiatry, UCSD School of Medicine, La Jolla, California, USA.
pubmed:publicationType
Journal Article, Review, Research Support, N.I.H., Extramural