@prefix activity: .
@prefix address: .
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@prefix biopax3: .
@prefix calbc: .
@prefix calbc-group: .
@prefix carrierLink: .
@prefix certainAgreement: .
@prefix chebi: .
@prefix chembl: .
@prefix chemicalCompound: .
@prefix chemicalCompoundRecord: .
@prefix clan: .
@prefix clinicalResult: .
@prefix clinicalStudy: .
@prefix clinicaltrials: .
@prefix company: .
@prefix confidenceScore: .
@prefix contact: .
@prefix country: .
@prefix cpath: .
@prefix curationLookup: .
@prefix dailymed: .
@prefix dailymed-drugs: .
@prefix dailymed-ingredient: .
@prefix dailymed-instance: .
@prefix databaseReference: .
@prefix dc: .
@prefix dc-term: .
@prefix diseaseontology: .
@prefix diseasome: .
@prefix diseasome-diseases: .
@prefix diseasome-gene: .
@prefix diseasome-instance: .
@prefix documentType: .
@prefix dosageForm: .
@prefix drug: .
@prefix drugbank: .
@prefix drugbank-proteinSequence: .
@prefix drugCategory: .
@prefix drugInteraction: .
@prefix drugTarget: .
@prefix eligibility: .
@prefix entrez-gene: .
@prefix entrez-goterm: .
@prefix entrezgene: .
@prefix enzymeLink: .
@prefix externalIdentifier: .
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@prefix factforge: .
@prefix family: .
@prefix foaf: .
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@prefix mixture: .
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@prefix outcomeAnalysis: .
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@prefix umls: .
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@prefix uniprot: .
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pubmed-article:16479161 a pubmed:Citation ;
lifeskim:mentions umls-concept:C1334913 , umls-concept:C1450355 , umls-concept:C1261381 , umls-concept:C0332281 , umls-concept:C1705165 , umls-concept:C1309143 , umls-concept:C1419246 , umls-concept:C1622911 , umls-concept:C1621812 , umls-concept:C0205421 , umls-concept:C2700061 ;
pubmed:issue "4" ;
pubmed:dateCreated "2006-3-15" ;
pubmed:abstractText "Precisely timed ubiquitin-mediated proteolysis of mitotic regulators by the anaphase-promoting complex (APC) governs the orderly passage of cells through mitosis. The established view is that Cdc20-activated APC (APC(Cdc20)) mediates the destruction of cyclin B and securin at the metaphase/anaphase transition, and that Cdh1-activated APC (APC(Cdh1)) has no role in this process. We recently reported that securin, but not cyclin B, is prematurely targeted for destruction by the APC in mutant mice that have low levels of the nuclear transport factors Rae1 and Nup98. We found that Rae1 and Nup98 assemble into a complex with APC(Cdh1) in prometaphase and act to delay APC(Cdh1)-mediated ubiquitination of securin until the metaphase/anaphase transition. Here we show that Rae1 and Nup98 not only form a complex with APC(Cdh1) in prometaphase but also with securin. This finding suggests that the Rae1-Nup98 complex does not inhibit early destruction of securin by preventing APC(Cdh1) from binding to securin, but by preventing ubiquitination of APC(Cdh1)-bound securin. We propose that the formation of APC(Cdh1)-securin complexes in prometaphase primes the cell for rapid securin degradation after release of the inhibitory Rae1-Nup98 complex at the metaphase/anaphase transition. We further report here that mutant mice with low levels of the Rae1-Nup98 complex are not prone to develop spontaneous tumors, despite massive aneuploidy. However, Rae1/Nup98 mutant mice are significantly more susceptible to DMBA-induced lung tumors than wild-type mice, indicating that combined Rae1/ Nup98 haplo-insufficiency does promote tumorigenesis when certain cancer-critical genes are also mutated." ;
pubmed:grant , ;
pubmed:language "eng" ;
pubmed:journal ;
pubmed:citationSubset "IM" ;
pubmed:chemical , , , , , , , , ;
pubmed:status "MEDLINE" ;
pubmed:month "Feb" ;
pubmed:issn "1551-4005" ;
pubmed:author , , ;
pubmed:issnType "Electronic" ;
pubmed:volume "5" ;
pubmed:owner "NLM" ;
pubmed:authorsComplete "Y" ;
pubmed:pagination "366-70" ;
pubmed:dateRevised "2007-11-14" ;
pubmed:meshHeading pubmed-meshheading:16479161-Animals , pubmed-meshheading:16479161-Mice , pubmed-meshheading:16479161-Neoplasms , , pubmed-meshheading:16479161-Aneuploidy , pubmed-meshheading:16479161-Anaphase , pubmed-meshheading:16479161-Metaphase , , , , , , pubmed-meshheading:16479161-Prometaphase ;
pubmed:year "2006" ;
pubmed:articleTitle "Securin associates with APCCdh1 in prometaphase but its destruction is delayed by Rae1 and Nup98 until the metaphase/anaphase transition." ;
pubmed:affiliation "Department of Pediatric and Adolescent Medicine, Mayo College of Medicine, Rochester, Minnesota 55905, USA." ;
pubmed:publicationType "Journal Article" , "Research Support, N.I.H., Extramural" .