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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1991-7-31
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pubmed:abstractText |
Okadaic acid and dinophysistoxin-1 (35-methylokadaic acid) induced hyperphosphorylation of a 58 kDa protein in primary human fibroblasts, due to inhibition of protein phosphatase 1 and 2A activities. The protein was present in the nuclear and cytosolic fractions. Its pI was 5.3. The hyperphosphorylated protein reacted with monoclonal and polyclonal anti-vimentin antibodies, but not with anti-nucleolin antibody. Phosphorylation of vimentin was stimulated in vitro by dinophysistoxin-1 dose-dependently in the presence of protein phosphatase 2A and protein kinases.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0006-291X
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
28
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pubmed:volume |
177
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1165-70
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:1647766-Blotting, Western,
pubmed-meshheading:1647766-Ethers, Cyclic,
pubmed-meshheading:1647766-Fibroblasts,
pubmed-meshheading:1647766-Humans,
pubmed-meshheading:1647766-Kinetics,
pubmed-meshheading:1647766-Marine Toxins,
pubmed-meshheading:1647766-Molecular Weight,
pubmed-meshheading:1647766-Okadaic Acid,
pubmed-meshheading:1647766-Phosphoprotein Phosphatases,
pubmed-meshheading:1647766-Phosphorylation,
pubmed-meshheading:1647766-Protein Phosphatase 1,
pubmed-meshheading:1647766-Protein Phosphatase 2,
pubmed-meshheading:1647766-Pyrans,
pubmed-meshheading:1647766-Vimentin
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pubmed:year |
1991
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pubmed:articleTitle |
Vimentin is hyperphosphorylated in primary human fibroblasts treated with okadaic acid.
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pubmed:affiliation |
Cancer Prevention Division, National Cancer Center Research Institute, Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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