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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2005-10-3
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pubmed:abstractText |
Experimental studies support an important role for endothelial nitric oxide synthase (eNOS) in the regulation of angiogenesis. In humans, a common polymorphism exists in the eNOS gene that results in the conversion of glutamate to aspartate for codon 298. In vitro and in vivo studies have suggested a decreased NOS activity in patients with the Asp298 variant. We hypothesized that a genetic-mediated decreased eNOS activity may limit collateral development in patients with chronic coronary occlusions.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16164743-10377070,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16164743-10510054,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16164743-10717002,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16164743-11331296,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16164743-11692081,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16164743-11738287,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16164743-12171788,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16164743-12388304,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16164743-12511546,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16164743-12586536,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16164743-12668492,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16164743-12756191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16164743-12875755,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16164743-14568906,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16164743-14664903,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16164743-15007011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16164743-15608562,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16164743-15797845,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16164743-2973212,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16164743-3156171,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16164743-3344216,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16164743-436205,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16164743-5576437,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16164743-7688726,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16164743-9169492,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16164743-9616228,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16164743-9674630,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16164743-9878950
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2261
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
27
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16164743-Chronic Disease,
pubmed-meshheading:16164743-Collateral Circulation,
pubmed-meshheading:16164743-Coronary Disease,
pubmed-meshheading:16164743-Female,
pubmed-meshheading:16164743-Genotype,
pubmed-meshheading:16164743-Humans,
pubmed-meshheading:16164743-Male,
pubmed-meshheading:16164743-Middle Aged,
pubmed-meshheading:16164743-Multivariate Analysis,
pubmed-meshheading:16164743-Nitric Oxide Synthase Type III,
pubmed-meshheading:16164743-Polymorphism, Genetic,
pubmed-meshheading:16164743-Sex Factors,
pubmed-meshheading:16164743-Smoking
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pubmed:year |
2005
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pubmed:articleTitle |
A common variant of endothelial nitric oxide synthase (Glu298Asp) is associated with collateral development in patients with chronic coronary occlusions.
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pubmed:affiliation |
Hôpital Cardiologique, Centre Hospitalier Universitaire de Lille, Place de Verdun, 59037 Lille cedex, France. nicolas.lamblin@pasteur-lille.fr
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pubmed:publicationType |
Journal Article
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