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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2005-10-12
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pubmed:abstractText |
Inhibition of rho-kinase has been shown to attenuate vasopressin (AVP)-induced myocardial ischemia measured as S-wave depression in Donryu rats. This has been attributed to a direct inhibitory effect on AVP-induced coronary vasoconstriction. However, since AVP also increased mean arterial blood pressure (MAP) which was attenuated by the rho-kinase inhibitors used, the prevention of myocardial ischemia could have been due to effects on afterload.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0031-7012
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pubmed:author |
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pubmed:copyrightInfo |
Copyright (c) 2005 S. Karger AG, Basel.
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pubmed:issnType |
Print
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pubmed:volume |
75
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
145-51
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:16158013-1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine,
pubmed-meshheading:16158013-Animals,
pubmed-meshheading:16158013-Arginine Vasopressin,
pubmed-meshheading:16158013-Blood Pressure,
pubmed-meshheading:16158013-Electrocardiography,
pubmed-meshheading:16158013-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:16158013-Male,
pubmed-meshheading:16158013-Myocardial Ischemia,
pubmed-meshheading:16158013-Protein-Serine-Threonine Kinases,
pubmed-meshheading:16158013-Rats,
pubmed-meshheading:16158013-Vasoconstriction,
pubmed-meshheading:16158013-Vasodilator Agents,
pubmed-meshheading:16158013-rho-Associated Kinases
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pubmed:year |
2005
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pubmed:articleTitle |
Inhibition of rho-kinase by hydroxyfasudil prevents vasopressin-induced myocardial ischemia in Donryu rats by attenuating coronary vasoconstriction.
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pubmed:affiliation |
Berlex Biosciences, Richmond, CA 94804, USA.
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pubmed:publicationType |
Journal Article
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