| pubmed-article:16156511 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16156511 | lifeskim:mentions | umls-concept:C0034705 | lld:lifeskim |
| pubmed-article:16156511 | lifeskim:mentions | umls-concept:C0027740 | lld:lifeskim |
| pubmed-article:16156511 | lifeskim:mentions | umls-concept:C0021516 | lld:lifeskim |
| pubmed-article:16156511 | lifeskim:mentions | umls-concept:C0003018 | lld:lifeskim |
| pubmed-article:16156511 | lifeskim:mentions | umls-concept:C0006669 | lld:lifeskim |
| pubmed-article:16156511 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:16156511 | lifeskim:mentions | umls-concept:C0301630 | lld:lifeskim |
| pubmed-article:16156511 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:16156511 | lifeskim:mentions | umls-concept:C0332256 | lld:lifeskim |
| pubmed-article:16156511 | lifeskim:mentions | umls-concept:C0443252 | lld:lifeskim |
| pubmed-article:16156511 | lifeskim:mentions | umls-concept:C1292733 | lld:lifeskim |
| pubmed-article:16156511 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:16156511 | pubmed:dateCreated | 2005-9-13 | lld:pubmed |
| pubmed-article:16156511 | pubmed:abstractText | The aim of this study was to investigate age-related changes in the density of calcitonin gene-related peptide (CGRP)-containing nerve fibers in spontaneously hypertensive rats (SHR) and the effects of long-term inhibition of the renin-angiotensin system on these changes. The density of immunocytochemically stained nerve fibers in the mesenteric artery was quantified by computer-assisted image processing. An age-related decrease in the density of CGRP-like immunoreactive (LI)-containing nerve fivers but not neuropeptide Y (NPY)-LI-containing sympathetic nerve fibers was found in the mesenteric artery of SHR but not Wistar Kyoto rats (WKY). The density of NPY-LI-containing sympathetic nerve fibers was significantly greater in SHR than in WKY. SHR were treated for 7 weeks with angiotensin converting enzyme inhibitor (0.005% temocapril), angiotensin II type-1 (AT1) receptor antagonist (0.025% losartan) or vasodilator (0.01% hydralazine) in their drinking water. Each drug treatment significantly lowered the systolic blood pressure measured by tail-cuff method. Long-term treatment of SHR with temocapril and losartan significantly increased the density of CGRP-LI-containing nerve fibers in mesenteric arteries. However, the density after hydralazine treatment was similar to the level in non-treated SHR. The density of NPY-LI-containing nerve fibers was not increased by any of the drug treatments. These results suggest that long-term inhibition of the renin-angiotensin system in SHR prevents remodeling of CGRPergic nerve fibers and prevents the reduction of CGRPergic nerve function. | lld:pubmed |
| pubmed-article:16156511 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16156511 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16156511 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16156511 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16156511 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16156511 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16156511 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16156511 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16156511 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16156511 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16156511 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16156511 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16156511 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16156511 | pubmed:month | May | lld:pubmed |
| pubmed-article:16156511 | pubmed:issn | 0916-9636 | lld:pubmed |
| pubmed-article:16156511 | pubmed:author | pubmed-author:KawasakiHirom... | lld:pubmed |
| pubmed-article:16156511 | pubmed:author | pubmed-author:TakayamaFusak... | lld:pubmed |
| pubmed-article:16156511 | pubmed:author | pubmed-author:KurosakiYujiY | lld:pubmed |
| pubmed-article:16156511 | pubmed:author | pubmed-author:HobaraNarumiN | lld:pubmed |
| pubmed-article:16156511 | pubmed:author | pubmed-author:AkiyamaShinji... | lld:pubmed |
| pubmed-article:16156511 | pubmed:author | pubmed-author:GodaMitsuhiro... | lld:pubmed |
| pubmed-article:16156511 | pubmed:author | pubmed-author:Gessei-Tsutsu... | lld:pubmed |
| pubmed-article:16156511 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16156511 | pubmed:volume | 28 | lld:pubmed |
| pubmed-article:16156511 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16156511 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16156511 | pubmed:pagination | 465-74 | lld:pubmed |
| pubmed-article:16156511 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:16156511 | pubmed:meshHeading | pubmed-meshheading:16156511... | lld:pubmed |
| pubmed-article:16156511 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16156511 | pubmed:articleTitle | Long-term inhibition of angiotensin prevents reduction of periarterial innervation of calcitonin gene-related peptide (CGRP)-containing nerves in spontaneously hypertensive rats. | lld:pubmed |
| pubmed-article:16156511 | pubmed:affiliation | Department of Clinical Pharmaceutical Science, Faculty of Pharmaceutical Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan. | lld:pubmed |
| pubmed-article:16156511 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16156511 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
