| pubmed-article:16093490 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16093490 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:16093490 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:16093490 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:16093490 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:16093490 | lifeskim:mentions | umls-concept:C0678640 | lld:lifeskim |
| pubmed-article:16093490 | lifeskim:mentions | umls-concept:C1948027 | lld:lifeskim |
| pubmed-article:16093490 | lifeskim:mentions | umls-concept:C0597484 | lld:lifeskim |
| pubmed-article:16093490 | lifeskim:mentions | umls-concept:C0205349 | lld:lifeskim |
| pubmed-article:16093490 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:16093490 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:16093490 | pubmed:dateCreated | 2005-8-11 | lld:pubmed |
| pubmed-article:16093490 | pubmed:abstractText | We have created genetically altered mice to investigate how expression of the Na(+)-Ca(2+) exchange protein alters excitation-contraction (E-C) coupling. Whereas low levels of exchanger overexpression have minimal effects on E-C coupling properties, high levels of overexpression in homozygous animals results in susceptibility to hypertrophy and heart failure, along with a significant reduction in E-C coupling gain. While global knockout of the exchanger in mice is embryonic-lethal, conditional knockout mice live to adulthood. Cardiac function is surprisingly normal in seven-week-old mice, but E-C coupling gain is apparently increased. Thus, genetic modification of exchanger expression has a major influence on E-C coupling. | lld:pubmed |
| pubmed-article:16093490 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16093490 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16093490 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16093490 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16093490 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16093490 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16093490 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16093490 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:16093490 | pubmed:issn | 0077-8923 | lld:pubmed |
| pubmed-article:16093490 | pubmed:author | pubmed-author:PhilipsonKenn... | lld:pubmed |
| pubmed-article:16093490 | pubmed:author | pubmed-author:ReuterHannesH | lld:pubmed |
| pubmed-article:16093490 | pubmed:author | pubmed-author:HendersonScot... | lld:pubmed |
| pubmed-article:16093490 | pubmed:author | pubmed-author:GoldhaberJosh... | lld:pubmed |
| pubmed-article:16093490 | pubmed:author | pubmed-author:PottChristian... | lld:pubmed |
| pubmed-article:16093490 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16093490 | pubmed:volume | 1047 | lld:pubmed |
| pubmed-article:16093490 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16093490 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16093490 | pubmed:pagination | 122-6 | lld:pubmed |
| pubmed-article:16093490 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:16093490 | pubmed:meshHeading | pubmed-meshheading:16093490... | lld:pubmed |
| pubmed-article:16093490 | pubmed:meshHeading | pubmed-meshheading:16093490... | lld:pubmed |
| pubmed-article:16093490 | pubmed:meshHeading | pubmed-meshheading:16093490... | lld:pubmed |
| pubmed-article:16093490 | pubmed:meshHeading | pubmed-meshheading:16093490... | lld:pubmed |
| pubmed-article:16093490 | pubmed:meshHeading | pubmed-meshheading:16093490... | lld:pubmed |
| pubmed-article:16093490 | pubmed:meshHeading | pubmed-meshheading:16093490... | lld:pubmed |
| pubmed-article:16093490 | pubmed:meshHeading | pubmed-meshheading:16093490... | lld:pubmed |
| pubmed-article:16093490 | pubmed:meshHeading | pubmed-meshheading:16093490... | lld:pubmed |
| pubmed-article:16093490 | pubmed:meshHeading | pubmed-meshheading:16093490... | lld:pubmed |
| pubmed-article:16093490 | pubmed:meshHeading | pubmed-meshheading:16093490... | lld:pubmed |
| pubmed-article:16093490 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16093490 | pubmed:articleTitle | Effects of Na+-Ca2+ exchange expression on excitation-contraction coupling in genetically modified mice. | lld:pubmed |
| pubmed-article:16093490 | pubmed:affiliation | Cardiovascular Research Laboratories, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA. jgoldhaber@mednet.ucla.edu | lld:pubmed |
| pubmed-article:16093490 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16093490 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:16093490 | pubmed:publicationType | Review | lld:pubmed |
| pubmed-article:16093490 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16093490 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
