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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2005-7-4
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pubmed:abstractText |
To investigate the immune-mediated response in TS, and its relationship with streptococcal infection, we measured serum levels of soluble intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin in patients with TS, compared to healthy and diseased controls. Soluble VCAM-1 and sE-selectin were significantly elevated in children and adults with TS, and sVCAM-1 was higher among anti-basal ganglia antibodies (ABGA)-positive adults with TS. No correlation of adhesion molecule levels to clinical severity or anti-streptococcal antibodies was observed. Children with Sydenham's chorea and paediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) showed an increased level of sICAM-1, but not sVCAM-1 and sE-selectin. These results provide initial evidence for a role of adhesion molecules and systemic inflammation in TS, and support the hypothesis of an ongoing immune-mediated process in this condition.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0022-510X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
234
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
79-85
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pubmed:dateRevised |
2007-5-24
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pubmed:meshHeading |
pubmed-meshheading:15941572-Adolescent,
pubmed-meshheading:15941572-Adult,
pubmed-meshheading:15941572-Age Factors,
pubmed-meshheading:15941572-Aged,
pubmed-meshheading:15941572-Analysis of Variance,
pubmed-meshheading:15941572-Antibodies,
pubmed-meshheading:15941572-Basal Ganglia,
pubmed-meshheading:15941572-Blotting, Western,
pubmed-meshheading:15941572-Cell Adhesion Molecules,
pubmed-meshheading:15941572-Child,
pubmed-meshheading:15941572-Child, Preschool,
pubmed-meshheading:15941572-Cullin Proteins,
pubmed-meshheading:15941572-Demography,
pubmed-meshheading:15941572-E-Selectin,
pubmed-meshheading:15941572-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:15941572-Female,
pubmed-meshheading:15941572-History, Ancient,
pubmed-meshheading:15941572-Humans,
pubmed-meshheading:15941572-Intercellular Adhesion Molecule-1,
pubmed-meshheading:15941572-Male,
pubmed-meshheading:15941572-Middle Aged,
pubmed-meshheading:15941572-Nervous System Diseases,
pubmed-meshheading:15941572-Receptors, Vasopressin,
pubmed-meshheading:15941572-Tourette Syndrome,
pubmed-meshheading:15941572-Trauma Severity Indices
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pubmed:year |
2005
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pubmed:articleTitle |
Soluble adhesion molecules in Gilles de la Tourette's syndrome.
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pubmed:affiliation |
Neuroimmunology Unit, Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK. davidemartino@virgilio.it
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pubmed:publicationType |
Journal Article,
Historical Article,
Research Support, Non-U.S. Gov't
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