Source:http://linkedlifedata.com/resource/pubmed/id/15935433
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2005-6-6
|
| pubmed:abstractText |
The gene coding for the dopamine receptor D3 (DRD3) is considered as a major candidate gene in various addictive disorders. Association studies in alcohol-dependence for this gene are nevertheless controversial. We made the hypothesis that phenotypical heterogeneity of alcohol-dependence (i.e. the DRD3 gene is a vulnerability gene in a specific subgroup of patients only) could explain these spurious findings, focusing on a core dimension of addictive disorders, namely impulsiveness. In our sample of 108 French alcohol-dependent patients, patients above the median value for cognitive impulsiveness (one of the three dimensions of the Barratt scale) were more frequently heterozygous than both alcohol-dependent patients with lower impulsiveness (OR = 2.51, P = 0.019) and than 71 healthy controls (OR = 2.32, P = 0.025). Age at interview, antisocial personality disorder, other comorbid addictive disorder, age at onset of alcohol-dependence, and lifetime mood disorders did not constitute confusing intermediate factors.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
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| pubmed:issn |
0924-9338
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
20
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
304-6
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:15935433-Adult,
pubmed-meshheading:15935433-Age Factors,
pubmed-meshheading:15935433-Age of Onset,
pubmed-meshheading:15935433-Alcoholism,
pubmed-meshheading:15935433-Antisocial Personality Disorder,
pubmed-meshheading:15935433-Cognition,
pubmed-meshheading:15935433-Comorbidity,
pubmed-meshheading:15935433-Gene Frequency,
pubmed-meshheading:15935433-Genetic Heterogeneity,
pubmed-meshheading:15935433-Humans,
pubmed-meshheading:15935433-Impulsive Behavior,
pubmed-meshheading:15935433-Interview, Psychological,
pubmed-meshheading:15935433-Male,
pubmed-meshheading:15935433-Mood Disorders,
pubmed-meshheading:15935433-Phenotype,
pubmed-meshheading:15935433-Polymorphism, Genetic,
pubmed-meshheading:15935433-Questionnaires,
pubmed-meshheading:15935433-Receptors, Dopamine D2,
pubmed-meshheading:15935433-Receptors, Dopamine D3,
pubmed-meshheading:15935433-Temperament
|
| pubmed:year |
2005
|
| pubmed:articleTitle |
Association between dopamine receptor D3 gene BalI polymorphism and cognitive impulsiveness in alcohol-dependent men.
|
| pubmed:affiliation |
Service de Psychiatrie Adulte, Faculty of medicine Bichat-Claude Bernard, Louis Mourier hospital (AP-HP), 178, rue des Renouillers, 92701 Colombes cedex, France.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|