| pubmed-article:15922295 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15922295 | lifeskim:mentions | umls-concept:C0011860 | lld:lifeskim |
| pubmed-article:15922295 | lifeskim:mentions | umls-concept:C0599779 | lld:lifeskim |
| pubmed-article:15922295 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:15922295 | lifeskim:mentions | umls-concept:C0068355 | lld:lifeskim |
| pubmed-article:15922295 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:15922295 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:15922295 | lifeskim:mentions | umls-concept:C1412113 | lld:lifeskim |
| pubmed-article:15922295 | lifeskim:mentions | umls-concept:C0231491 | lld:lifeskim |
| pubmed-article:15922295 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:15922295 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:15922295 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:15922295 | pubmed:dateCreated | 2005-6-13 | lld:pubmed |
| pubmed-article:15922295 | pubmed:abstractText | This study was undertaken to reveal the role of NAD(P)H oxidase in increased oxidative stress in islets of Type 2 diabetes. Immunostaining analysis showed that staining intensities of NAD(P)H oxidase components, gp91phox and p22phox, significantly increased in islets of animal models of Type 2 diabetes, OLETF rats (60 weeks of age) and db/db mice (14 weeks of age), compared with age-matched controls, respectively, correlating with increased levels of oxidative stress marker, 8-hydroxy-deoxyguanosine or 4-hydroxy-2-nonenal modified protein. In db/db mice, oral administration of angiotensin II Type 1 receptor antagonist valsartan (5 mg/kg) for 4 weeks significantly attenuated the increased expression of gp91phox and p22phox together with inhibition of oxidative stress and partially restored decreased insulin contents in islets. Angiotensin II-related increased expression of NAD(P)H oxidase may play an important role in increased oxidative stress in islets of Type 2 diabetes. This mechanism may be a novel therapeutic target for preventing beta-cell damage. | lld:pubmed |
| pubmed-article:15922295 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:15922295 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15922295 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:15922295 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:15922295 | pubmed:author | pubmed-author:WallerC ACA | lld:pubmed |
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| pubmed-article:15922295 | pubmed:author | pubmed-author:KobayashiKuni... | lld:pubmed |
| pubmed-article:15922295 | pubmed:author | pubmed-author:SonodaNoriyuk... | lld:pubmed |
| pubmed-article:15922295 | pubmed:author | pubmed-author:SasakiShujiS | lld:pubmed |
| pubmed-article:15922295 | pubmed:author | pubmed-author:NakayamaMieko... | lld:pubmed |
| pubmed-article:15922295 | pubmed:author | pubmed-author:MaedaYasutaka... | lld:pubmed |
| pubmed-article:15922295 | pubmed:author | pubmed-author:SawadaFumiF | lld:pubmed |
| pubmed-article:15922295 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15922295 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:15922295 | pubmed:volume | 332 | lld:pubmed |
| pubmed-article:15922295 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15922295 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15922295 | pubmed:pagination | 927-33 | lld:pubmed |
| pubmed-article:15922295 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:15922295 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15922295 | pubmed:articleTitle | Increased expression of NAD(P)H oxidase in islets of animal models of Type 2 diabetes and its improvement by an AT1 receptor antagonist. | lld:pubmed |
| pubmed-article:15922295 | pubmed:affiliation | Department of Medicine and Bioregulatory Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan. | lld:pubmed |
| pubmed-article:15922295 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15922295 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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