. . "2" . "2005-5-18" . "High-risk human papillomavirus are essential for the development of cervical cancer; however, TP53 is the most frequently altered tumor suppressor gene among tumors and is described as a cofactor for cervical carcinogenesis. TP53 has two common polymorphic forms encoding either proline or arginine, at position 72, and the presence of homozygous arginine has been reported as a risk factor for cervical cancer in many populations. We evaluated the effect of this TP53 polymorphism in a northern Portuguese population. We analyzed blood samples of 385 women; 20 with low-grade squamous intraepithelial lesion (SIL), 56 with high-grade SIL, 164 with invasive cervical cancer, and 145 healthy controls, using allele specific-polymerase chain reaction methodology. We observed an increased frequency of the Arg/Arg genotype in the cancer group, but no statistical significance was found between cases and controls (P>0.05). Our results indicate that there is no association between the presence of the Arg allele in codon 72 of TP53 polymorphism and risk of cervical cancer in our population." . "eng" . . "IM" . . "MEDLINE" . "Jun" . "0165-4608" . . . . . . . . . . "Print" . "159" . "NLM" . "Y" . "143-7" . "2006-11-15" . . . . . . . . . . . "2005" . "TP53 codon 72 polymorphism and risk for cervical cancer in Portugal." . "Molecular Oncology Unit, Portuguese Institute of Oncology-Porto, Laborat\u00F3rios 4 Piso, Rua Dr. Ant\u00F3nio Bernardino Almeida, 4200-072 Porto, Portugal." . "Journal Article" . "Research Support, Non-U.S. Gov't" . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .