Linked Life Data

15837762

Source:http://linkedlifedata.com/resource/pubmed/id/15837762

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2005-4-19
pubmed:abstractText
The type I insulin-like growth factor receptor (IGF-IR) and its ligands have been shown to play a critical role in prostate carcinoma development, growth, and metastasis. Targeting the IGF-IR may be a potential treatment for prostate cancer. A fully human monoclonal antibody, A12, specific to IGF-IR, has shown potent antitumor effects in breast, colon, and pancreatic cancers in vitro and in vivo. In this study, we tested the in vivo effects of A12 on androgen-dependent and androgen-independent prostate tumor growth.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1078-0432
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3065-74
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:15837762-Androgens, pubmed-meshheading:15837762-Animals, pubmed-meshheading:15837762-Antibodies, Monoclonal, pubmed-meshheading:15837762-Apoptosis, pubmed-meshheading:15837762-Cell Cycle, pubmed-meshheading:15837762-Cell Line, Tumor, pubmed-meshheading:15837762-Cell Proliferation, pubmed-meshheading:15837762-Humans, pubmed-meshheading:15837762-Male, pubmed-meshheading:15837762-Mice, pubmed-meshheading:15837762-Mice, SCID, pubmed-meshheading:15837762-Orchiectomy, pubmed-meshheading:15837762-Phosphorylation, pubmed-meshheading:15837762-Prostate-Specific Antigen, pubmed-meshheading:15837762-Prostatic Neoplasms, pubmed-meshheading:15837762-Protein-Serine-Threonine Kinases, pubmed-meshheading:15837762-Proto-Oncogene Proteins, pubmed-meshheading:15837762-Proto-Oncogene Proteins c-akt, pubmed-meshheading:15837762-Receptor, IGF Type 1, pubmed-meshheading:15837762-Signal Transduction, pubmed-meshheading:15837762-Time Factors, pubmed-meshheading:15837762-Xenograft Model Antitumor Assays
pubmed:year
2005
pubmed:articleTitle
In vivo effects of the human type I insulin-like growth factor receptor antibody A12 on androgen-dependent and androgen-independent xenograft human prostate tumors.
pubmed:affiliation
Department of Medicine, University of Washington, Seattle, Washington 98104, USA. wuj@u.washington.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, N.I.H., Extramural