| pubmed-article:15358172 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15358172 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:15358172 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:15358172 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:15358172 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:15358172 | lifeskim:mentions | umls-concept:C0332453 | lld:lifeskim |
| pubmed-article:15358172 | lifeskim:mentions | umls-concept:C0058400 | lld:lifeskim |
| pubmed-article:15358172 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:15358172 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:15358172 | pubmed:dateCreated | 2004-9-13 | lld:pubmed |
| pubmed-article:15358172 | pubmed:abstractText | We have established a transgenic mouse line in which floxed neomycin resistant cassette was inserted between the CAG promoter and EGFP. When these transgenic mice were mated with Cre-expressing transgenic animals, the offspring obtained were fluorescent green. We then established a transgenic mouse line in which EGFP in the above construct was replaced by diphtheria toxin A chain (DT). When the latter transgenic mice were mated with mice expressing Cre restricted to germ cells, we obtained healthy but sterile offspring due to a disruption of germ line cells by DT expression. We predict that this strategy will be useful for the construction of new animal models for human diseases, featuring a variety of missing cell lineages produced by disruption with DT. | lld:pubmed |
| pubmed-article:15358172 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15358172 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15358172 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15358172 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15358172 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15358172 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15358172 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15358172 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15358172 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15358172 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15358172 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:15358172 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:15358172 | pubmed:author | pubmed-author:OkabeMasaruM | lld:pubmed |
| pubmed-article:15358172 | pubmed:author | pubmed-author:IkawaMasahito... | lld:pubmed |
| pubmed-article:15358172 | pubmed:author | pubmed-author:InoueNaokazuN | lld:pubmed |
| pubmed-article:15358172 | pubmed:author | pubmed-author:HasuwaHidetos... | lld:pubmed |
| pubmed-article:15358172 | pubmed:author | pubmed-author:MatsumuraHiro... | lld:pubmed |
| pubmed-article:15358172 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15358172 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:15358172 | pubmed:volume | 321 | lld:pubmed |
| pubmed-article:15358172 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15358172 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15358172 | pubmed:pagination | 275-9 | lld:pubmed |
| pubmed-article:15358172 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:15358172 | pubmed:meshHeading | pubmed-meshheading:15358172... | lld:pubmed |
| pubmed-article:15358172 | pubmed:meshHeading | pubmed-meshheading:15358172... | lld:pubmed |
| pubmed-article:15358172 | pubmed:meshHeading | pubmed-meshheading:15358172... | lld:pubmed |
| pubmed-article:15358172 | pubmed:meshHeading | pubmed-meshheading:15358172... | lld:pubmed |
| pubmed-article:15358172 | pubmed:meshHeading | pubmed-meshheading:15358172... | lld:pubmed |
| pubmed-article:15358172 | pubmed:meshHeading | pubmed-meshheading:15358172... | lld:pubmed |
| pubmed-article:15358172 | pubmed:meshHeading | pubmed-meshheading:15358172... | lld:pubmed |
| pubmed-article:15358172 | pubmed:meshHeading | pubmed-meshheading:15358172... | lld:pubmed |
| pubmed-article:15358172 | pubmed:meshHeading | pubmed-meshheading:15358172... | lld:pubmed |
| pubmed-article:15358172 | pubmed:meshHeading | pubmed-meshheading:15358172... | lld:pubmed |
| pubmed-article:15358172 | pubmed:meshHeading | pubmed-meshheading:15358172... | lld:pubmed |
| pubmed-article:15358172 | pubmed:meshHeading | pubmed-meshheading:15358172... | lld:pubmed |
| pubmed-article:15358172 | pubmed:meshHeading | pubmed-meshheading:15358172... | lld:pubmed |
| pubmed-article:15358172 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15358172 | pubmed:articleTitle | Lineage-specific cell disruption in living mice by Cre-mediated expression of diphtheria toxin A chain. | lld:pubmed |
| pubmed-article:15358172 | pubmed:affiliation | Faculty of Pharmaceutical Sciences, Osaka University, Japan. | lld:pubmed |
| pubmed-article:15358172 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15358172 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15358172 | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15358172 | lld:pubmed |
