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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2004-8-31
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pubmed:abstractText |
Specific mutations in the cationic trypsinogen gene ( PRSS1) are disease-causing in patients with hereditary pancreatitis, but the genetic background still remains mysterious in about 40% of patients with the disease. It has been suggested that oxidative stress contributes to pancreatic damage. The glutathione s-transferases (GSTs) represent major detoxification enzymes that protect cells from oxidative stress.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0944-1174
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
39
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
783-7
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15338373-Adolescent,
pubmed-meshheading:15338373-Adult,
pubmed-meshheading:15338373-Age Factors,
pubmed-meshheading:15338373-Aged,
pubmed-meshheading:15338373-Child,
pubmed-meshheading:15338373-Child, Preschool,
pubmed-meshheading:15338373-Chronic Disease,
pubmed-meshheading:15338373-DNA Mutational Analysis,
pubmed-meshheading:15338373-Exons,
pubmed-meshheading:15338373-Female,
pubmed-meshheading:15338373-Gene Frequency,
pubmed-meshheading:15338373-Genetic Predisposition to Disease,
pubmed-meshheading:15338373-Glutathione Transferase,
pubmed-meshheading:15338373-Homozygote,
pubmed-meshheading:15338373-Humans,
pubmed-meshheading:15338373-Infant,
pubmed-meshheading:15338373-Male,
pubmed-meshheading:15338373-Middle Aged,
pubmed-meshheading:15338373-Open Reading Frames,
pubmed-meshheading:15338373-Oxidative Stress,
pubmed-meshheading:15338373-Pancreatitis,
pubmed-meshheading:15338373-Polymerase Chain Reaction,
pubmed-meshheading:15338373-Polymorphism, Genetic,
pubmed-meshheading:15338373-Prognosis,
pubmed-meshheading:15338373-Reference Values,
pubmed-meshheading:15338373-Trypsin,
pubmed-meshheading:15338373-Trypsinogen
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pubmed:year |
2004
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pubmed:articleTitle |
Genetic analysis of the glutathione s-transferase genes MGST1, GSTM3, GSTT1, and GSTM1 in patients with hereditary pancreatitis.
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pubmed:affiliation |
Department of Medicine, Division of Gastroenterology, University of Pittsburgh, 571 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15213, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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