| pubmed-article:15231039 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15231039 | lifeskim:mentions | umls-concept:C0225336 | lld:lifeskim |
| pubmed-article:15231039 | lifeskim:mentions | umls-concept:C0242606 | lld:lifeskim |
| pubmed-article:15231039 | lifeskim:mentions | umls-concept:C1996904 | lld:lifeskim |
| pubmed-article:15231039 | lifeskim:mentions | umls-concept:C1880497 | lld:lifeskim |
| pubmed-article:15231039 | lifeskim:mentions | umls-concept:C0101334 | lld:lifeskim |
| pubmed-article:15231039 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:15231039 | pubmed:dateCreated | 2004-7-2 | lld:pubmed |
| pubmed-article:15231039 | pubmed:abstractText | The protective effect of acteoside against membrane lipid oxidation and free radical-mediated impairment of endothelial function was investigated. Results showed that iron-mediated oxidative modification of the cell membrane in cultured bovine pulmonary endothelial cells (PAECs) was significantly attenuated by acteoside as measured by thiobarbituric acid-reactive substances (TBARS). Fenton's reagent (H2O2/Fe2+) was used to generate hydroxyl radicals (*OH) and induce oxidative stress. Acteoside not only effectively minimized the loss of cell viability induced by hydroxyl radicals in cultured endothelial cells but also countered the free radical-induced destruction of the endothelium-dependent relaxation to acetylcholine in rat aorta. Furthermore, acteoside showed a dose-dependent scavenging effect of 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radicals and appeared to be the most efficient in comparison with the four reference compounds (alpha-tocopherol, vitamin C, probucol and resveratrol). These data suggested that acteoside protects the cell from oxidative stress and that scavenging of free radicals could be a key mechanism contributing to the cytoprotective effect of acteoside. | lld:pubmed |
| pubmed-article:15231039 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15231039 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15231039 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15231039 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15231039 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15231039 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15231039 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15231039 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15231039 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15231039 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15231039 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15231039 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15231039 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15231039 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15231039 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:15231039 | pubmed:issn | 0022-3573 | lld:pubmed |
| pubmed-article:15231039 | pubmed:author | pubmed-author:ChiouWen... | lld:pubmed |
| pubmed-article:15231039 | pubmed:author | pubmed-author:LinLie... | lld:pubmed |
| pubmed-article:15231039 | pubmed:author | pubmed-author:ChenChieh... | lld:pubmed |
| pubmed-article:15231039 | pubmed:copyrightInfo | Copyright 2004 The Authors | lld:pubmed |
| pubmed-article:15231039 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15231039 | pubmed:volume | 56 | lld:pubmed |
| pubmed-article:15231039 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15231039 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15231039 | pubmed:pagination | 743-8 | lld:pubmed |
| pubmed-article:15231039 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:15231039 | pubmed:meshHeading | pubmed-meshheading:15231039... | lld:pubmed |
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| pubmed-article:15231039 | pubmed:meshHeading | pubmed-meshheading:15231039... | lld:pubmed |
| pubmed-article:15231039 | pubmed:meshHeading | pubmed-meshheading:15231039... | lld:pubmed |
| pubmed-article:15231039 | pubmed:meshHeading | pubmed-meshheading:15231039... | lld:pubmed |
| pubmed-article:15231039 | pubmed:meshHeading | pubmed-meshheading:15231039... | lld:pubmed |
| pubmed-article:15231039 | pubmed:meshHeading | pubmed-meshheading:15231039... | lld:pubmed |
| pubmed-article:15231039 | pubmed:meshHeading | pubmed-meshheading:15231039... | lld:pubmed |
| pubmed-article:15231039 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15231039 | pubmed:articleTitle | Acteoside protects endothelial cells against free radical-induced oxidative stress. | lld:pubmed |
| pubmed-article:15231039 | pubmed:affiliation | National Research Institute of Chinese Medicine, NO. 155-1, SEC. 2, Li-Nung Street, Shipai, Taipei, Taiwan. wfchiou@cma23@.nricm.edu.tw | lld:pubmed |
| pubmed-article:15231039 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15231039 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:15231039 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
