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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2004-7-2
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pubmed:abstractText |
The protective effect of acteoside against membrane lipid oxidation and free radical-mediated impairment of endothelial function was investigated. Results showed that iron-mediated oxidative modification of the cell membrane in cultured bovine pulmonary endothelial cells (PAECs) was significantly attenuated by acteoside as measured by thiobarbituric acid-reactive substances (TBARS). Fenton's reagent (H2O2/Fe2+) was used to generate hydroxyl radicals (*OH) and induce oxidative stress. Acteoside not only effectively minimized the loss of cell viability induced by hydroxyl radicals in cultured endothelial cells but also countered the free radical-induced destruction of the endothelium-dependent relaxation to acetylcholine in rat aorta. Furthermore, acteoside showed a dose-dependent scavenging effect of 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radicals and appeared to be the most efficient in comparison with the four reference compounds (alpha-tocopherol, vitamin C, probucol and resveratrol). These data suggested that acteoside protects the cell from oxidative stress and that scavenging of free radicals could be a key mechanism contributing to the cytoprotective effect of acteoside.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2,2-diphenyl-1-picrylhydrazyl,
http://linkedlifedata.com/resource/pubmed/chemical/Antioxidants,
http://linkedlifedata.com/resource/pubmed/chemical/Biphenyl Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Glucosides,
http://linkedlifedata.com/resource/pubmed/chemical/Hydrazines,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Lipids,
http://linkedlifedata.com/resource/pubmed/chemical/Phenols,
http://linkedlifedata.com/resource/pubmed/chemical/Picrates,
http://linkedlifedata.com/resource/pubmed/chemical/Thiobarbituric Acid Reactive...,
http://linkedlifedata.com/resource/pubmed/chemical/acteoside
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0022-3573
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2004 The Authors
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pubmed:issnType |
Print
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pubmed:volume |
56
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
743-8
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:15231039-Animals,
pubmed-meshheading:15231039-Antioxidants,
pubmed-meshheading:15231039-Aorta, Thoracic,
pubmed-meshheading:15231039-Biphenyl Compounds,
pubmed-meshheading:15231039-Cattle,
pubmed-meshheading:15231039-Cell Death,
pubmed-meshheading:15231039-Cells, Cultured,
pubmed-meshheading:15231039-Endothelium, Vascular,
pubmed-meshheading:15231039-Glucosides,
pubmed-meshheading:15231039-Hydrazines,
pubmed-meshheading:15231039-Male,
pubmed-meshheading:15231039-Membrane Lipids,
pubmed-meshheading:15231039-Oxidative Stress,
pubmed-meshheading:15231039-Phenols,
pubmed-meshheading:15231039-Picrates,
pubmed-meshheading:15231039-Pulmonary Artery,
pubmed-meshheading:15231039-Rats,
pubmed-meshheading:15231039-Rats, Sprague-Dawley,
pubmed-meshheading:15231039-Thiobarbituric Acid Reactive Substances,
pubmed-meshheading:15231039-Vasodilation
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pubmed:year |
2004
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pubmed:articleTitle |
Acteoside protects endothelial cells against free radical-induced oxidative stress.
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pubmed:affiliation |
National Research Institute of Chinese Medicine, NO. 155-1, SEC. 2, Li-Nung Street, Shipai, Taipei, Taiwan. wfchiou@cma23@.nricm.edu.tw
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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