Linked Life Data

15215397

Source:http://linkedlifedata.com/resource/pubmed/id/15215397

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
Web Server issue
pubmed:dateCreated
2004-6-24
pubmed:abstractText
Statistical and clustering analyses of gene expression results from high-density microarray experiments produce lists of hundreds of genes regulated differentially, or with particular expression profiles, in the conditions under study. Independent of the microarray platforms and analysis methods used, these lists must be biologically interpreted to gain a better knowledge of the patho-physiological phenomena involved. To this end, numerous biological annotations are available within heterogeneous and widely distributed databases. Although several tools have been developed for annotating lists of genes, most of them do not give methods for evaluating the relevance of the annotations provided, or for estimating the functional bias introduced by the gene set on the array used to identify the gene list considered. We developed Genome Functional INtegrated Discoverer (GFINDer), a web server able to automatically provide large-scale lists of user-classified genes with functional profiles biologically characterizing the different gene classes in the list. GFINDer automatically retrieves annotations of several functional categories from different sources, identifies the categories enriched in each class of a user-classified gene list and calculates statistical significance values for each category. Moreover, GFINDer enables the functional classification of genes according to mined functional categories and the statistical analysis is of the classifications obtained, aiding better interpretation of microarray experiment results. GFINDer is available online at http://www.medinfopoli.polimi.it/GFINDer/.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/15215397-10391217, http://linkedlifedata.com/resource/pubmed/commentcorrection/15215397-10592173, http://linkedlifedata.com/resource/pubmed/commentcorrection/15215397-10802651, http://linkedlifedata.com/resource/pubmed/commentcorrection/15215397-11125071, http://linkedlifedata.com/resource/pubmed/commentcorrection/15215397-11752273, http://linkedlifedata.com/resource/pubmed/commentcorrection/15215397-12519953, http://linkedlifedata.com/resource/pubmed/commentcorrection/15215397-12520024, http://linkedlifedata.com/resource/pubmed/commentcorrection/15215397-12540299, http://linkedlifedata.com/resource/pubmed/commentcorrection/15215397-12702209, http://linkedlifedata.com/resource/pubmed/commentcorrection/15215397-14975175, http://linkedlifedata.com/resource/pubmed/commentcorrection/15215397-14990455, http://linkedlifedata.com/resource/pubmed/commentcorrection/15215397-9045213, http://linkedlifedata.com/resource/pubmed/commentcorrection/15215397-9223186, http://linkedlifedata.com/resource/pubmed/commentcorrection/15215397-9382993, http://linkedlifedata.com/resource/pubmed/commentcorrection/15215397-9399808
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1362-4962
pubmed:author
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
W293-300
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
GFINDer: Genome Function INtegrated Discoverer through dynamic annotation, statistical analysis, and mining.
pubmed:affiliation
Bioengineering Department, Politecnico di Milano, I-20133 Milano, Italy. masseroli@biomed.polimi.it
pubmed:publicationType
Journal Article