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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1993-2-17
|
| pubmed:abstractText |
The age-related changes in the morphology and function of rat adrenal zona glomerulosa (ZG) were investigated by coupled stereological and radioimmunological techniques. For this purpose 4-, 8-, 16- and 24-month-old rats were studied. Aging caused a notable lowering in the plasma aldosterone concentration and a marked decrease in both basal and ACTH- or angiotensin II (ANG-II)-stimulated secretion of collagenase-dispersed ZG cells. Plasma renin activity (PRA) underwent an age-dependent decrease, while the plasma level of ACTH displayed a significant rise. ZG and its parenchymal cells did not evidence any age-related morphologically demonstrable alteration in their growth, nor ZG cells showed any marked ultrastructural change, with the exception of a severe lipid-droplet repletion. This last finding is in keeping with the aging-induced decrease in the secretory activity of ZG cells, inasmuch as lipid droplets are the intra-cellular stores of cholesterol esters, the obligate precursors of steroid hormones in rat adrenals. ACTH and ANG-II are well known to be involved in the maintenance of the growth of rat ZG; thus, the combined impairment of ANG-II production (as evidenced by PRA lowering) and increase in ACTH secretion may maintain unchanged ZG growth during aging.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0040-8166
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
24
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
835-42
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:1485325-Aging,
pubmed-meshheading:1485325-Animals,
pubmed-meshheading:1485325-Cell Count,
pubmed-meshheading:1485325-Male,
pubmed-meshheading:1485325-Microscopy, Electron,
pubmed-meshheading:1485325-Radioimmunoassay,
pubmed-meshheading:1485325-Rats,
pubmed-meshheading:1485325-Rats, Wistar,
pubmed-meshheading:1485325-Zona Glomerulosa
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Age-related changes in the morphology and function of the zona glomerulosa of the rat adrenal cortex.
|
| pubmed:affiliation |
Department of Anatomy, University of Padua, Italy.
|
| pubmed:publicationType |
Journal Article
|